TY - JOUR AU - Kannisto, Kati Anneli AU - Korhonen, Joonas AU - Adams, Clive E AU - Koivunen, Marita Hannele AU - Vahlberg, Tero AU - Välimäki, Maritta Anneli PY - 2017 DA - 2017/02/21 TI -基于移动健康的随机对照试验招募期间退出的相关因素。网络鼓励对有严重精神健康问题的人的治疗坚持JO - J医学Internet Res SP - e46 VL - 19 IS - 2kw -短信KW -移动健康KW -抗精神病药物KW -精神健康KW -精神科服务KW -方法学研究AB -背景:临床试验是循证实践的金标准。仍有许多论文在随机对照试验(rct)中报告方法不足，特别是在对有严重精神健康问题的人进行移动健康干预方面。为了确保足够有力的证据，重要的是要了解哪些研究阶段在精神卫生保健领域是最脆弱的。目的:我们绘制了参与者的招募和试验随访期，以提供基于健康的试验的退出预测因素的图片。例如，我们使用了一个名为“移动”的基于移动健康的多中心随机对照试验。”，针对的是有严重心理健康问题的人。方法:对流动人员进行招聘和随访。对网络试验进行监测和分析。招募结果被记录为筛选、合格、未经询问、拒绝和登记。患者参与记录为随访结果:(1)短消息服务(SMS)短信干预期间的损耗(2)12个月随访期间的损耗。采用多元回归分析来确定哪些人口因素与招聘和留任有关。 Results: We recruited 1139 patients during a 15-month period. Of 11,530 people screened, 36.31% (n=4186) were eligible. This eligible group tended to be significantly younger (mean 39.2, SD 13.2 years, P<.001) and more often women (2103/4181, 50.30%) than those who were not eligible (age: mean 43.7, SD 14.6 years; women: 3633/6514, 55.78%). At the point when potential participants were asked to give consent, a further 2278 refused. Those who refused were a little older (mean 40.2, SD 13.9 years) than those who agreed to participate (mean 38.3, SD 12.5 years; t1842=3.2, P<.001). We measured the outcomes after 12 months of the SMS text message intervention. Attrition from the SMS text message intervention was 4.8% (27/563). The patient dropout rate after 12 months was 0.36% (4/1123), as discovered from the register data. In all, 3.12% (35/1123) of the participants withdrew from the trial. However, dropout rates from the patient survey (either by paper or telephone interview) were 52.45% (589/1123) and 27.8% (155/558), respectively. Almost all participants (536/563, 95.2%) tolerated the intervention, but those who discontinued were more often women (21/27, 78%; P=.009). Finally, participants’ age (P<.001), gender (P<.001), vocational education (P=.04), and employment status (P<.001) seemed to predict their risk of dropping out from the postal survey. Conclusions: Patient recruitment and engagement in the 12-month follow-up conducted with a postal survey were the most vulnerable phases in the SMS text message-based trial. People with serious mental health problems may need extra support during the recruitment process and in engaging them in SMS text message-based trials to ensure robust enough evidence for mental health care. ClinicalTrial: International Standard Randomized Controlled Trial Number (ISRCTN): 27704027; http://www.isrctn.com/ISRCTN27704027 (Archived by WebCite at http://www.webcitation.org/6oHcU2SFp) SN - 1438-8871 UR - //www.mybigtv.com/2017/2/e46/ UR - https://doi.org/10.2196/jmir.6417 UR - http://www.ncbi.nlm.nih.gov/pubmed/28223262 DO - 10.2196/jmir.6417 ID - info:doi/10.2196/jmir.6417 ER -