%0杂志文章%@ 1438- 8871% I JMIR出版物%V 22卡塔尔世界杯8强波胆分析% N 6% P e17446% T人乳头瘤病毒疫苗接种后不良事件的积极监测:基于宁波市区域卫生保健信息平台的可行性试点研究刘a，张志科，杨梁，余A孟，方若谷，董婷，李颖，徐宁，詹国章，思燕+北京大学医学部流行病学与生物统计系，北京市海淀区学院路38号，100191,86 13641084052，siyan-zhan@bjmu.edu.cn %K安全性%K HPV %K人乳头瘤病毒%K疫苗%K主动监测%D 2020 %7 1.6.2020 %9原始论文%J J医学互联网Res %G英文%X背景:来自许可后监测的全面疫苗安全性数据，特别是主动监测，可以指导管理部门和个人做出合理的疫苗接种决策。因此，我们设计了一项试点研究，以评估区域卫生保健信息平台积极监测新获许可疫苗安全性的能力。目的:本研究旨在基于该信息平台对人乳头瘤病毒(HPV)疫苗安全性进行主动监测。方法:2017年选择国内最成熟、数据联动优势的信息平台之一。制定结构化问卷和开放式访谈指南，以调查利用宁波市区域卫生保健信息平台进行HPV疫苗接种后主动监测的可行性。调查问卷通过电子邮件发送给参与者，并进行面对面访谈以确认细节或解决差异。结果:从2015年开始，五个可被认为对疫苗安全性主动监测至关重要的数据库被纳入该平台。除居民健康档案的覆盖率为87%外，数据来源覆盖了宁波市95%以上的记录。 All the data could be inherently linked using the national identity card. There were 19,328 women who received the HPV vaccine, and 37,988 doses were administered in 2017 and 2018. Women aged 30-40 years accounted for the largest proportion. Quadrivalent vaccination accounted for 73.1% of total vaccination, a much higher proportion than that of bivalent vaccination. Of the first doses, 60 (60/19,328, 0.31%) occurred outside Ningbo. There were no missing data for vaccination-relevant variables, such as identity card, vaccine name, vaccination doses, vaccination date, and manufacturer. ICD-10 coding could be used to identify 9,180 cases using a predefined list of the outcomes of interest, and 1.88% of these cases were missing the identity card. During the 90 days following HPV vaccination, 4 incident cases were found through the linked vaccination history and electronic medical records. The combined incident rate of rheumatoid arthritis, optic neuritis, and Henoch-Schonlein purpura was 8.84/100,000 doses of bivalent HPV, and the incidence rate of rheumatoid arthritis was 3.75/100,000 doses of quadrivalent HPV. Conclusions: This study presents an available approach to initiate an active surveillance system for adverse events following HPV vaccination, based on a regional health care information platform in China. An extended observation period or the inclusion of additional functional sites is warranted to conduct future hypothesis-generating and hypothesis-confirming studies for vaccine safety concerns. %M 32234696 %R 10.2196/17446 %U //www.mybigtv.com/2020/6/e17446 %U https://doi.org/10.2196/17446 %U http://www.ncbi.nlm.nih.gov/pubmed/32234696