微信干预(Run4Love)对中国艾滋病毒感染者抑郁症状的影响卡塔尔世界杯8强波胆分析随机对照试验%A Guo， %A Hong,Y Alicia %A Cai， %A Li， %A Li， %A Hao， %A Qiao, jiying %A Xu,Zhimeng %A Zhang， % Hanxi %A Zeng，程波%A Liu，聪%A Li,Yiran %A Zhu,Mengting %A Zeng,Yu %A Penedo,Frank J %+美国乔治梅森大学卫生与公共服务学院卫生行政与政策系，4400 University Dr MS 1J3，弗吉尼亚州Fairfax, 177039931929，yhong22@gmu.edu %K HIV %K抑郁%K mHealth %K微信%K随机对照试验%D 2020 %7 11.2.2020 %9原论文%J J医学互联网研究%G英语%X背景:HIV感染者(PLWH)抑郁症状发生率高。然而，针对这一弱势群体的有效心理健康干预措施很少。目的:本研究的目的是通过一项随机对照试验，评估基于微信的干预措施Run4Love的疗效，该试验在中国300名艾滋病毒和抑郁症(PLWHD)患者中进行。方法:我们从华南地区HIV门诊招募PLWH。参与者根据流行病学研究中心抑郁量表(CES-D)进行筛选。得分在16分以上的学生才有资格参加。共有300名符合条件的患者入组。在获得参与者的知情同意，完成基线调查，收集参与者的头发样本用于测量皮质醇后，参与者按1:1的比例随机分配到干预组或对照组。 The intervention group received the Run4Love program, delivered via the popular social media app WeChat. Cognitive behavioral stress management courses and weekly reminders of exercise were delivered in a multimedia format. Participants’ progress was monitored with timely and tailored feedback. The control group received usual care and a brochure on nutrition for PLWH. Data were collected at 3, 6, and 9 months. The primary outcome was depression, which was measured by a validated instrument. Results: Participants in the intervention and control groups were comparable at baseline; about 91.3% (139/150), 88.3% (132/150), and 86.7% (130/150) participants completed the 3-, 6-, and 9-month follow-ups, respectively. At the 3-month follow-up, a significant reduction in CES-D score was observed in the intervention group (from 23.9 to 17.7 vs from 24.3 to 23.8; mean difference=−5.77, 95% CI −7.82 to −3.71; P<.001; standard effect size d=0.66). The mean changes in CES-D score from baseline to the 6- and 9-month follow-ups between the two groups remained statistically significant. No adverse events were reported. Conclusions: The WeChat-based mobile health (mHealth) intervention Run4Love significantly reduced depressive symptoms among PLWHD, and the effect was sustained. An app-based mHealth intervention could provide a feasible therapeutic option for many PLWHD in resource-limited settings. Further research is needed to assess generalizability and cost-effectiveness of this intervention. Trial Registration: Chinese Clinical Trial Registry ChiCTR-IPR-17012606; http://www.chictr.org.cn/showproj.aspx?proj=21019 (Archived by WebCite at https://www.webcitation.org/78Bw2vouF) %R 10.2196/16715 %U //www.mybigtv.com/2020/2/e16715 %U https://doi.org/10.2196/16715