%0期刊文章%@ 1438- 8871% I JMIR出版物%V 19卡塔尔世界杯8强波胆分析% N 8% P e278% T慢性疾病症状负担和功能的个体预后:基于患者报告结果(PRO)测量的通用方法%A Hjollund,Niels Henrik Ingvar %+ WestChronic，职业医学，奥胡斯大学大学研究诊所，Gl. Landevej 61, Herning，丹麦，45 25850902，niehjo@rm.dk %K慢性疾病%K队列研究%K抑郁症%K纵向研究%K患者报告的结果测量%K预后%K功能恢复%K重复测量%K卒中%K调查和问卷%K症状评估%D 2017 %7 01.08.2017 %9原始论文%J J医学互联网Res %G英语%X背景:向患者提供有关症状负担和功能的长期预后的信息是临床实践的一个组成部分，但主要依赖于临床医生的个人经验。基于重复测量的患者报告结果(PRO)数据的相关预后模型很少可用。目的:目的是描述一种隐含很少统计假设的个体症状负担和功能的长期预后的通用方法，以评估脑卒中患者抑郁症状预后的实现，并提供该实现的基于web的原型供个人使用。方法:用于描述PRO结果的个体预后的方法是基于选择与相关患者在同一时间(如诊断或治疗开始后)具有相同评分的特定亚队列患者，加上或减去一个单位的最小临床重要差异。然后使用该子队列的经验课程，随着时间的推移，提供预后的定量测量。1404名脑卒中患者的队列研究为模拟研究提供了数据，并为个人使用提供了原型。该队列的成员在3.5年的时间里每6个月回答一次问卷。 Depressive symptoms were assessed by the Hospital Anxiety and Depression Scale (HADS) and a single item from the SF-12 (MH4) health survey. Four approaches were compared in a simulation study in which the prognosis for each member of the cohort was individually assessed. Results: The mean standard deviations were 40% to 70% higher in simulated scores. Mean errors were close to zero, and mean absolute errors were between 0.46 and 0.66 SD in the four approaches. An approach in which missing HADS scores were estimated from the single-item SF-12 MH4 performed marginally better than methods restricted to questionnaires with a genuine HADS score, which indicates that data collected with shorter questionnaires (eg, in clinical practice) may be used together with longer versions with the full scale, given that the design includes at least two simultaneous measurements of the full scale and the surrogate measure. Conclusions: This is the first description and implementation of a nonparametric method for individual PRO-based prognosis. Given that relevant PRO data have been collected longitudinally, the method may be applied to other patient groups and to any outcome related to symptom burden and functioning. This initial implementation has been deliberately made simple, and further elaborations as well as the usability and clinical validity of the method will be scrutinized in clinical practice. An implementation of the prototype is available online at www.prognosis.dk. %M 28765099 %R 10.2196/jmir.8111 %U //www.mybigtv.com/2017/8/e278/ %U https://doi.org/10.2196/jmir.8111 %U http://www.ncbi.nlm.nih.gov/pubmed/28765099