期刊文章Gunther Eysenbach基于web的商业减肥计划中的重量变化及其与网站使用的关系:队列研究%A Neve,Melinda %A Morgan,Philip J %A Collins,Clare E %+纽卡斯尔大学卫生学院，体育活动和营养优先研究中心，先进技术中心(三级)，大学大道，新南威尔士州卡拉汉，新南威尔士州，澳大利亚，61 61 2 49215405,melinda.neve@newcastle.edu.au %K减肥%K肥胖%K干预%K互联网%K商业%D 2011 %7 12.10.2011 %9原创论文%J J医学互联网Res %G英语%X背景:在科学文献中，关于商业减肥项目(包括基于网络的项目)的有效性的信息非常匮乏。基于网络的减肥计划的潜力已被承认，但其实现显著减肥的能力尚未得到证实。目的:本研究的目的是评估一大批参加商业网络减肥项目12周或52周的个体实现的体重变化，并描述参与者的项目使用与体重变化的关系。方法:参与者从2007年8月15日到2008年5月31日参加了一个澳大利亚的基于网络的商业减肥项目。使用每周自我报告的体重记录来确定12周和52周订阅后的体重变化。初步分析使用广义线性混合模型(glmm)估计了所有订阅了12周和订阅了52周的参与者的体重变化。采用最后一次观测结转(LOCF)方法进行敏感性分析。网站使用(即参与者登录的天数，在基于网络的日记中进行食物或运动记录，或发布到讨论论坛)描述了从项目注册到12周和52周，并使用Kruskal-Wallis检验人群平等的百分比体重变化类别测试网站使用的差异。 Results: Participants (n = 9599) had a mean (standard deviation [SD]) age of 35.7 (9.5) years and were predominantly female (86% or 8279/9599) and obese (61% or 5866/9599). Results from the primary GLMM analysis including all enrollees found the mean percentage weight change was −6.2% among 12-week subscribers (n = 6943) and −6.9% among 52-week subscribers (n = 2656). Sensitivity analysis using LOCF revealed an average weight change of −3.0% and −3.5% after 12 and 52 weeks respectively. The use of all website features increased significantly (P < .01) as percentage weight change improved. Conclusions: The weight loss achieved by 12- and 52-week subscribers of a commercial Web-based weight loss program is likely to be in the range of the primary and sensitivity analysis results. While this suggests that, on average, clinically important weight loss may be achieved, further research is required to evaluate the efficacy of this commercial Web-based weight loss program prospectively using objective measures. The potential association between greater website use and increased weight loss also requires further evaluation, as strategies to improve participants’ use of Web-based program features may be required. %M 21993231 %R 10.2196/jmir.1756 %U //www.mybigtv.com/2011/4/e83/ %U https://doi.org/10.2196/jmir.1756 %U http://www.ncbi.nlm.nih.gov/pubmed/21993231