@Article{info:doi/10.2196/21465，作者=“Wang, Zixin and Lau, Joseph T F and Ip, Tsun Kwan Mary and Yu, Yebo and Fong, Francois and Fang, Yuan and Mo, Phoenix K H”，标题=“两种基于网络和理论的干预:有和没有简短动机访谈对促进中国男男性行为者人乳头瘤病毒疫苗接种的影响:随机对照试验”，期刊=“J Med Internet Res”，年=“2021”，月=“Feb”，日=“2”，卷=“23”，数=“2”，页=“e21465”，关键词=“HPV疫苗接种;基于网络的健康促进;随机对照试验;与男性发生性关系的男性;中国;摘要="背景:人乳头瘤病毒(HPV)疫苗接种在男男性行为者(MSM)中有效预防疫苗型生殖器疣和癌症。目的:本随机对照试验(RCT)的主要目的是评估两种基于网络和理论的干预措施的有效性，通过电话进行简短的动机访谈(MI)，与对照组相比，在24个月的随访期内增加未接种疫苗的参与者的HPV疫苗接种完成情况。方法:于2017年7月至2019年12月进行3臂平行组随机对照试验。5个电话调查分别在基线和3、6、9和24个月由盲法采访者进行。 Participants were Hong Kong Chinese--speaking MSM aged between 18 and 45 years with regular internet access who were recruited from outreaching at venues, web-based recruitment, and peer referral. Those who had ever received HPV vaccination were excluded. A total of 624 participants were randomized into either the online tutorial (OT) only group (n=208), the OT plus MI group (OT-MI; n=208), or the control group (n=208). In total, 459 (459/624, 73.6{\%}) completed the follow-up evaluation at 24 months. Participants in the OT group received a fully automated OT developed based on the health belief model. On top of the same OT, the OT-MI group received brief MI over the phone. Reminders were sent to the participants of the OT and OT-MI groups after 1, 2, 4, 6, and 8 months. Participants in the control group received web-based health communication messages unrelated to HPV or HPV vaccination. The research team validated the self-reported HPV vaccination uptake. Intention-to-treat analysis was used for outcome analyses. Logistic regression models and multivariable linear regression models were used to test the between-group differences in primary and secondary outcomes. Baron and Kenny's methods were used to test the mediation hypothesis. Results: The participants in the OT-MI group reported a significantly higher validated completion of HPV vaccination at 24 months than the control group (36/208, 17.3{\%} vs 15/208, 7.2{\%}; P=.006). However, the difference in HPV vaccination completion between the OT and the control groups (24/208, 11.5{\%} vs 15/208, 7.2{\%}; P=.17), or between OT-MI and OT groups (P=.13), was not statistically significant. The association between randomization status (OT-MI group vs control group) and HPV vaccination completion became statistically nonsignificant after controlling for changes in the perceived susceptibility to HPV (24 months vs baseline), whereas perceived susceptibility remained strongly associated with HPV vaccination uptake in the model (P<.001). Changes in perceived susceptibility fully mediated the intervention effect. Conclusions: Theory-based OT with brief MI over the phone was effective in increasing HPV vaccination completion among Chinese MSM. Perceived susceptibility is an active theoretical component that causes behavioral changes. Trial Registration: ClinicalTrials.gov NCT03286907; https://clinicaltrials.gov/ct2/show/NCT03286907 ", issn="1438-8871", doi="10.2196/21465", url="//www.mybigtv.com/2021/2/e21465", url="https://doi.org/10.2196/21465", url="http://www.ncbi.nlm.nih.gov/pubmed/33528372" }