@文章{信息:doi/10.2196/15532，作者=“Bonacini, Maurizio和Kim, Yoona和Pitney, Caroline和McKoin, Lee和Tran, Melody和Landis, Charles”，标题=“无线观察疗法优化口服丙型肝炎治疗依从性和目标干预:观察性试点研究”，期刊=“J Med Internet Res”，年=“2020”，月=“4”，日=“30”，卷=“22”，数=“4”，页=“e15532”，关键词=“慢性丙型肝炎;丙肝病毒;合规;持续病毒学反应;抗病毒药物;背景:ledipasvir/sofosbuvir (LDV/SOF)固定剂量联合治疗慢性丙型肝炎病毒(HCV)感染有效;然而，在现实世界的临床环境中，对处方方案的客观依从性尚未得到很好的研究。目的:本研究旨在评估使用LDV/SOF治疗的慢性HCV感染患者的依从性和病毒学结果，使用一种新的数字医学程序，直接测量药物摄入依从性。方法:这项前瞻性、观察性、开放标签、单臂试验研究在2个临床研究地点进行，随访了处方LDV/SOF并使用可消化传感器的HCV感染患者。患者分别治疗8周或12周。 The main outcomes were ingestion adherence, medical interventions, virologic response, safety, and patient satisfaction. Results: Of the 28 patients (mean 59 years, SD 7), 61{\%} (17/28) were male, 61{\%} (17/28) were non-Caucasian, and 93{\%} (26/28) were treatment na{\"i}ve. All 28 had genotype 1 HCV, and of these, 27 completed an 8- or 12-week treatment. Patients used the digital medicine program for 92{\%} of the expected days; the overall mean ingestion adherence rate was 97{\%}. Providers used the digital medicine program data for same-day medication therapy management in 39{\%} (11/28) of patients. End-of-treatment response was achieved in all the available 21 of 28 patients. Sustained virologic response at 12 weeks or more was achieved in 26 of 28 patients; of the 2 patients who relapsed, one had less than 90{\%} adherence and the other had greater than or equal to 95{\%} adherence, lending insights into reasons for treatment failure. A total of 4 subjects reported nonserious adverse events, which were resolved. Conclusions: The findings of this study suggest that digital medicines can be used for wirelessly observed therapy to support adherence to antiviral HCV therapy, reduce unnecessary medication wastage and retreatment costs, and potentially optimize sustained virologic response rates, especially in populations at high risk for nonadherence. ", issn="1438-8871", doi="10.2196/15532", url="//www.mybigtv.com/2020/4/e15532", url="https://doi.org/10.2196/15532", url="http://www.ncbi.nlm.nih.gov/pubmed/32352385" }