@文章{信息:doi/10.2196/12556，作者=“Moberg, Christine和Niles, Andrea和Beermann, Dale”，标题=“引导自助作品:Pacifica的随机等待列表控制试验，一个移动应用程序集成认知行为治疗和压力，焦虑和抑郁的正念”，期刊=“J医学互联网研究”，年=“2019”，月=“Jun”，日=“8”，卷=“21”，数=“6”，页=“e12556”，关键词=“mHealth;焦虑;抑郁症;压力;认知行为疗法;背景:尽管技术有了长足的进步，消费者对技术支持的行为健康工具的需求也在增加，但在减轻精神疾病负担方面却几乎没有进展。这可能是因为在快速发展的技术环境中进行传统临床试验的固有挑战。目的:本研究旨在验证Pacifica的有效性，Pacifica是一款流行的商用应用程序，用于轻度至中度压力、焦虑和抑郁的自我管理。方法:从应用程序内入职招募了500名患有轻度至中度焦虑或抑郁的成年人，参与Pacifica的随机等待列表对照试验。我们进行了一项全虚拟研究，通过基于web的参与者门户网站招募、筛选和随机选择参与者。 Study participants used the app for 1 month, with no level of use required, closely mimicking real-world app usage. Participants in the waitlist group were given access to the app after 1 month. Measurements included self-reported symptoms of stress, anxiety, depression, and self-efficacy. We performed an intent-to-treat analysis to examine the interactive effects of time and condition. Results: We found significant interactions between time and group. Participants in the active condition demonstrated significantly greater decreases in depression, anxiety, and stress and increases in self-efficacy. Although we did not find a relationship between overall engagement with the app and symptom improvement, participants who completed relatively more thought record exercises sustained improvements in their symptoms through the 2-month follow-up to a greater degree than those who completed fewer. In addition, we found that participants who reported concomitantly taking psychiatric medications during the trial benefitted less from the app, as measured by the symptoms of anxiety and stress. Conclusions: This study provides evidence that Pacifica, a popular commercially available self-help app, is effective in reducing self-reported symptoms of depression, anxiety, and stress, particularly among individuals who utilize thought records and are not taking psychiatric medication. Trial Registration: ClinicalTrials.gov NCT03333707; https://clinicaltrials.gov/ct2/show/NCT03333707 (Archived by WebCite at http://www.webcitation.org/78YE07ADB) ", issn="1438-8871", doi="10.2196/12556", url="//www.mybigtv.com/2019/6/e12556/", url="https://doi.org/10.2196/12556", url="http://www.ncbi.nlm.nih.gov/pubmed/31199319" }