%0期刊文章%@ 2561- 6722% I JMIR出版物%V 5%卡塔尔世界杯8强波胆分析 N 4% P e31579% T妊娠与冠状病毒细胞因子风暴的关系:系统评价和元分析，肯尼亚医学培训学院，邮箱30195-00100，肯尼亚内罗毕，254 724274843,A Muthuka,John, A Kiptoo,Michael, A Oluoch,Kelly, A Nziokijohnmuthuka@gmail.com %K COVID-19 %K大流行%K怀孕%K孕产妇健康%K细胞因子%K细胞因子风暴%K免疫反应%K传染病%K冠状病毒%K呼吸道%K病毒%K怀孕%D 2022 %7 4.10.2022 %9回顾%J JMIR儿童父母%G英语%X背景:2019年12月在中国武汉首次发现COVID-19，传播到全球其他地区，成为大流行。一些研究表明，怀孕状态与严重的COVID-19之间存在细胞因子风暴，而另一些研究则显示出相反的结果。目的:本研究旨在通过系统综述和meta分析，探讨妊娠状态与以细胞因子风暴为特征的COVID-19临床严重程度之间的关系。方法:我们检索了谷歌Scholar、PubMed、Scopus、Web of Science和Embase数据库，以确定适合纳入本荟萃分析的临床研究。包括报告怀孕状况和比较COVID-19严重程度的细胞因子风暴结果的研究。以细胞因子风暴为特征的COVID-19严重程度，采用重症监护病房入院、有创机械通气、机械通气、住院、促和抗炎细胞因子水平、胸部计算机断层扫描实变、肺浸润、作为细胞因子风暴特征的极端发热、综合征严重程度、较高的中性粒细胞计数指示细胞因子风暴，以及严重的COVID-19表现等参数进行描述。结果:共纳入17篇文章，包括840332名COVID-19女性患者的数据。这项荟萃分析揭示了阳性妊娠状态与严重COVID-19与细胞因子风暴之间的相关性(随机效应模型优势比[OR] 2.47, 95% CI 1.63-3.73; P<.001), with a cumulative incidence of 6432 (14.1%) and 24,352 (3.1%) among pregnant and nonpregnant women with COVID-19, respectively. The fixed-effects model also showed a correlation between pregnancy status and severe COVID-19 with a cytokine storm (OR 7.41, 95% CI 7.02-7.83; P<.001). Considerable heterogeneity was found among all pooled studies (I²=98%, P<.001). Furthermore, the updated analysis showed substantially low heterogeneity (I²=29 %, P=.19), and the funnel plot revealed no publication bias. The subanalysis between single-center and multicenter studies demonstrated similar heterogeneity (I2=72% and 98%, respectively). Sensitivity analysis on each subgroup revealed that pregnancy was significantly related to severe COVID-19 with a cytokine storm from single-center studies (fixed-effects model OR 3.97, 95% CI 2.26-6.95; P<.001) with very low heterogeneity (I²=2%, P=.42). Conclusions: Being pregnant is clearly associated with experiencing a severe course of COVID-19 characterized by a cytokine storm. The COVID-19 pandemic should serve as an impetus for further research on pregnant women diagnosed with COVID-19 to map out the salient risk factors associated with its severity. Trial Registration: PROSPERO CRD42021242011; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=242011. %M 35319475 %R 10.2196/31579 %U https://pediatrics.www.mybigtv.com/2022/4/e31579 %U https://doi.org/10.2196/31579 %U http://www.ncbi.nlm.nih.gov/pubmed/35319475