德国和英国在COVID-19措施之前和期间来自症状评估应用程序的综合征卡塔尔世界杯8强波胆分析监测见解:重复横断面分析结果%A Mehl,Alicia %A Bergey,Francois %A Cawley,Caoimhe %A Gilsdorf,Andreas %+ Ada Health GmbH流行病学与公共卫生学系，Karl-Liebknecht-Str 1，柏林，10178，德国，49 30 403 67 390，alicia.mehl@ada.com %K流行病学%K参与式流行病学%K参与式监测%K COVID-19症状评估应用程序%K症状检查应用程序%K综合征监测%K COVID-19措施%K COVID-19封锁%K数字公共卫生%K COVID-19措施对健康的影响，信息监测%D 2020 %7 9.10.2020 %9原论文%J JMIR Mhealth Uhealth %G英文%X世界各国采取了前所未有的封锁措施，以减轻COVID-19的传播和后果。虽然人们一直把注意力集中在这些措施对与感染直接有关的流行病学指标的影响上，但人们越来越认识到这些措施对健康的更广泛影响。然而，由于现有综合征监测数据和工具的局限性，实时评估这些影响是一项挑战。目的:本研究旨在探讨基于手机应用程序的症状评估工具作为实时健康洞察提供者的附加价值，为公共卫生决策者提供信息。方法:对德国和英国实施“第一阶段”COVID-19防控措施前后两个时间段内，Ada应用程序内用户自行报告的所有症状所占比例进行比较和描述性分析。还进行了进一步的分析，以探讨症状趋势与季节性以及症状趋势与天气之间的关系。使用Pearson卡方检验分析不同时期独特症状比例的差异，并以log2倍变化报告。 Results: Overall, 48,300-54,900 symptomatic users reported 140,500-170,400 symptoms during the Baseline and Measures periods in Germany. Overall, 34,200-37,400 symptomatic users in the United Kingdom reported 112,100-131,900 symptoms during the Baseline and Measures periods. The majority of symptomatic users were female (Germany: 68,600/103,200, 66.52%; United Kingdom: 51,200/71,600, 72.74%). The majority were aged 10-29 years (Germany: 68,500/100,000, 68.45%; United Kingdom: 50,900/68,800, 73.91%), and about one-quarter were aged 30-59 years (Germany: 26,200/100,000, 26.15%; United Kingdom: 14,900/68,800, 21.65%). Overall, 103 symptoms were reported either more or less frequently (with statistically significant differences) during the Measures period as compared to the Baseline period, and 34 of these were reported in both countries. The following mental health symptoms (log2 fold change, P value) were reported less often during the Measures period: inability to manage constant stress and demands at work (–1.07, P<.001), memory difficulty (–0.56, P<.001), depressed mood (–0.42, P<.001), and impaired concentration (–0.46, P<.001). Diminished sense of taste (2.26, P<.001) and hyposmia (2.20, P<.001) were reported more frequently during the Measures period. None of the 34 symptoms were found to be different between the same dates in 2019. In total, 14 of the 34 symptoms had statistically significant associations with weather variables. Conclusions: Symptom assessment apps have an important role to play in facilitating improved understanding of the implications of public health policies such as COVID-19 lockdown measures. Not only do they provide the means to complement and cross-validate hypotheses based on data collected through more traditional channels, they can also generate novel insights through a real-time syndromic surveillance system. %M 32997640 %R 10.2196/21364 %U http://mhealth.www.mybigtv.com/2020/10/e21364/ %U https://doi.org/10.2196/21364 %U http://www.ncbi.nlm.nih.gov/pubmed/32997640