@文章{info:doi/10.2196/22229，作者="Byonanebye, Dathan Mirembe和Nabaggala, Maria S和Naggirinya, Agnes Bwanika和Lamorde, Mohammed和Oseku, Elizabeth和King, Rachel和Owarwo, Noela和Laker, Eva和Orama, Richard和Castelnuovo, Barbara和Kiragga, Agnes和帕克斯- ratanshi, Rosalind"，标题="一个交互式语音响应软件，改善乌干达艾滋病毒感染者的生活质量:随机对照试验"，期刊="JMIR Mhealth Uhealth"，年="2021"，月="Feb"，日="11"，卷="9"，数="2"，页数="e22229"，关键词=" Mhealth;艾滋病毒;生活质量;交互式语音应答;移动健康;背景:在成功扩大抗逆转录病毒治疗(ART)之后，现在的重点是确保艾滋病毒感染者的良好生活质量和持续的病毒抑制。在负担最重的国家，获得移动技术的机会正在迅速增加，因此，可以利用移动卫生技术改善艾滋病毒感染者的生活质量。然而，关于移动健康工具对艾滋病毒感染者生活质量影响的数据仅限于对短信短信的评估;这些在高文盲环境中是不可行的。 Objective: The primary and secondary outcomes were to determine the impact of interactive voice response (IVR) technology on Medical Outcomes Study HIV QoL scores and viral suppression at 12 months, respectively. Methods: Within the Call for Life study, ART-experienced and ART-na{\"i}ve people living with HIV commencing ART were randomized (1:1 ratio) to the control (no IVR support) or intervention arm (daily adherence and pre-appointment reminders, health information tips, and option to report symptoms). The software evaluated was Call for Life Uganda, an IVR technology that is based on the Mobile Technology for Community Health open-source software. Eligibility criteria for participation included access to a phone, fluency in local languages, and provision of consent. The differences in differences (DIDs) were computed, adjusting for baseline HIV RNA and CD4. Results: Overall, 600 participants (413 female, 68.8{\%}) were enrolled and followed-up for 12 months. In the intervention arm of 300 participants, 298 (99.3{\%}) opted for IVR and 2 (0.7{\%}) chose SMS text messaging as the mode of receiving reminders and health tips. At 12 months, there was no overall difference in the QoL between the intervention and control arms (DID=0.0; P=.99) or HIV RNA (DID=0.01; P=.94). At 12 months, 124 of the 256 (48.4{\%}) active participants had picked up at least 50{\%} of the calls. In the active intervention participants, high users (received >75{\%} of reminders) had overall higher QoL compared to low users (received <25{\%} of reminders) (92.2 versus 87.8, P=.02). Similarly, high users also had higher QoL scores in the mental health domain (93.1 versus 86.8, P=.008) and better appointment keeping. Similarly, participants with moderate use (51{\%}-75{\%}) had better viral suppression at 12 months (80/94, 85{\%} versus 11/19, 58{\%}, P=.006). Conclusions: Overall, there was high uptake and acceptability of the IVR tool. While we found no overall difference in the QoL and viral suppression between study arms, people living with HIV with higher usage of the tool showed greater improvements in QoL, viral suppression, and appointment keeping. With the declining resources available to HIV programs and the increasing number of people living with HIV accessing ART, IVR technology could be used to support patient care. The tool may be helpful in situations where physical consultations are infeasible, including the current COVID epidemic. Trial Registration: ClinicalTrials.gov NCT02953080; https://clinicaltrials.gov/ct2/show/NCT02953080 ", issn="2291-5222", doi="10.2196/22229", url="https://mhealth.www.mybigtv.com/2021/2/e22229", url="https://doi.org/10.2196/22229", url="http://www.ncbi.nlm.nih.gov/pubmed/33570497" }