信息-动机-行为技能模型在聚类随机试验中的应用JO - J Med Internet Res SP - e37848 VL - 24 IS - 9 KW -人乳头瘤病毒疫苗接种KW -网络教育KW -信息-动机-行为技能模型KW -女大学生KW -中国AB -背景:近20年确诊宫颈癌患者以年轻女性为主。人类乳头瘤病毒(HPV)疫苗接种是预防HPV感染和子宫颈癌的最根本方法。然而，中国大陆大部分女大学生尚未接种疫苗，相关知识有限。通过互联网提供的基于理论的教育是在这一人群中推广HPV疫苗接种的一种潜在的可行和有用的方式。目的:这项为期3个月的随访研究旨在确定基于信息-动机-行为技能(IMB)模型的在线干预的可行性和有效性，以提高女大学生对HPV疫苗接种的认识和意愿。方法:采用聚类随机试验设计，针对中国大陆女大学生开展为期7天的在线HPV教育项目。招聘和问卷调查在网上进行，没有面对面的接触。采用SPSS 23.0进行统计分析。采用卡方检验和t检验比较干预组和对照组定性变量和连续变量的差异。 The generalized estimating equation was used to test the effectiveness of the intervention with a consideration of the time factor. Results: Among 3867 participants, 102 had been vaccinated against HPV before the study (vaccination rate of 2.6%). A total of 3484 participants were followed up after the baseline survey, with no statistical difference in the loss rate between the intervention and control groups during the intervention and follow-up periods. At different follow-up time points, HPV-related knowledge, and the motivation, behavioral skills, and willingness regarding HPV vaccination were higher in the intervention group than in the control group. HPV-related knowledge was statistically different between the 2 groups, while the motivation, behavioral skills, and willingness regarding HPV vaccination only showed statistical differences right after the intervention, reaching a peak right after the intervention and then gradually reducing over time. Furthermore, there was no statistical difference in the HPV vaccination rate between the 2 groups. Conclusions: IMB model–based online education could be a promising way to increase the HPV vaccination rate and reduce the burden of HPV infection and cervical cancer among high-risk female college students in China. Trial Registration: Chinese Clinical Trial Registry ChiCTR1900025476; http://www.chictr.org.cn/showprojen.aspx? proj=42672 International Registered Report Identifier (IRRID): RR2-DOI:10.1186/s12889-019-7903-x SN - 1438-8871 UR - //www.mybigtv.com/2022/9/e37848 UR - https://doi.org/10.2196/37848 UR - http://www.ncbi.nlm.nih.gov/pubmed/36178723 DO - 10.2196/37848 ID - info:doi/10.2196/37848 ER -