TY - JOUR AU - Lamaj, Ganimete AU - Pablo-Trinidad, Alberto AU - Butterworth, Ian AU - Bell, Nolan AU - Benasutti, Ryan AU - Bourquard, Aurelien AU - Sanchez-Ferro, Alvaro AU - Castro-Gonzalez, Carlos AU - Jiménez-Ubieto, Ana AU - Baumann, Tycho AU - Rodriguez-Izquierdo, Antonia AU - Pottier, Elizabeth AU - Shelton, Anthony AU - Martinez-Lopez, Joaquin AU - Sloan，John Mark PY - 2022 DA - 2022/8/9 TI -用于接受癌症化疗患者的无创中性粒细胞减少筛查设备(PointCheck)的可用性评估:混合方法观察研究JO - J医学互联网Res SP - e37368 VL - 24 IS - 8kw -数字健康KW -可用性KW -以患者为中心的护理KW -远程监测KW -决策支持系统KW -白细胞KW -诊断KW -医疗设备KW -癌症KW -化疗KW -感染KW -白细胞KW -技术AB -背景:接受细胞毒性化疗的癌症患者由于治疗而面临严重感染的风险增加，这降低了他们的白细胞计数，更具体地说，降低了他们的绝对中性粒细胞计数。这种情况被称为中性粒细胞减少症。伴有发热的中性粒细胞减少症被称为发热性中性粒细胞减少症，是化疗的一种常见副作用，死亡率高。及时发现严重的中性粒细胞减少症(<500绝对中性粒细胞计数/μL)对于发现和处理发热性中性粒细胞减少症至关重要。目前的方法依赖于抽血，这将它们限制在临床环境中，不允许频繁或便携式监测。在这项研究中，我们在没有临床监督的模拟家庭环境中演示了PointCheck的可用性，PointCheck是一种用于中性粒细胞减少症筛查的非侵入性设备。PointCheck自动通过手指皮肤进行显微检查，对流经浅表微毛细血管的血液进行成像，并实现对中性粒细胞减少状态的远程监测，而不需要静脉穿刺。 Objective: This study aimed to evaluate the usability of PointCheck, a noninvasive optical technology for screening severe neutropenia, with the goal of identifying potential user interface, functionality, and design issues from the perspective of untrained users. Methods: We conducted a multicenter study using quantitative and qualitative approaches to evaluate the usability of PointCheck across 154 untrained participants. We used a mixed method approach to gather usability data through user testing observations, a short-answer qualitative questionnaire, and a standardized quantitative System Usability Scale (SUS) survey to assess perceived usability and satisfaction. Results: Of the 154 participants, we found that 108 (70.1%) scored above 80.8 on the SUS across all sites, with a mean SUS score of 86.1 across all sites. Furthermore, the SUS results indicated that, out of the 151 users who completed the SUS survey, 145 (96%) found that they learned how to use PointCheck very quickly, and 141 (93.4%) felt very confident when using the device. Conclusions: We have shown that PointCheck, a novel technology for noninvasive, home-based neutropenia detection, can be safely and effectively operated by first-time users. In a simulated home environment, these users found it easy to use, with a mean SUS score of 86.1, indicating an excellent perception of usability and placing this device within the top tenth percentile of systems evaluated for usability by the SUS. Trial Registration: ClinicalTrials.gov NCT04448314; https://clinicaltrials.gov/ct2/show/NCT04448314 (Hospital Universitario 12 de Octubre registration) and NCT04448301; https://clinicaltrials.gov/ct2/show/NCT04448301 (Boston Medical Center registration) SN - 1438-8871 UR - //www.mybigtv.com/2022/8/e37368 UR - https://doi.org/10.2196/37368 UR - http://www.ncbi.nlm.nih.gov/pubmed/35943786 DO - 10.2196/37368 ID - info:doi/10.2196/37368 ER -