TY - JOUR AU - Mujcic, Ajla AU - Blankers, Matthijs AU - Boon, Brigitte AU - Berman, Anne H AU - Riper, Heleen AU - van Laar, Margriet AU - Engels, Rutger PY - 2022 DA - 2022/2/1 TI -数字酒精调节干预对癌症幸存者的有效性、成本-效果和成本-效用:JO - J Med Internet Res SP - e30095 VL - 24 IS - 2kw -酒精-简短干预KW -癌症幸存者KW -有效性KW -成本效益KW - eHealth KW -移动电话AB -背景:酒精调节(AM)干预可能有助于更好的治疗结果和癌症幸存者的总体福祉。目的:本研究评估了数字AM干预MyCourse的有效性、成本效益和成本效用，并与非交互式数字癌症幸存者信息手册进行了比较。方法:采用实用的两臂平行组随机对照试验进行健康经济评估，并在随机化后3、6和12个月进行随访。这项研究于2016年至2019年在荷兰的网上进行。参与者是成年10年癌症幸存者，饮酒超过荷兰推荐的饮酒指南(每周≤7标准单位[10克酒精])，并有意适度或戒酒。总体而言，103名参与者被随机化并进行分析:MyCourse组53人(51.5%)，对照组50人(48.5%)。在“我的课程”组中，参与者可以获得一种新开发的、数字的、最低限度引导的AM干预，“我的课程-适度饮酒”。主要结果是在6个月随访时，在过去7天内摄入标准饮料(10克乙醇)的自我报告数量。次要结局指标是酒精使用障碍鉴定测试(AUDIT)测量的酒精相关问题和治疗满意度。 For the health economic evaluation, health care costs, costs because of productivity losses, and intervention costs were assessed over a 12-month horizon. Results: Alcohol use at the 6-month follow-up decreased by 38% in the MyCourse group and by 33% in the control group. No difference in 7-day alcohol use was found between the groups (B=2.1, 95% CI −7.6 to 3.1; P=.22) at any of the follow-ups. AUDIT scores for alcohol-related problems decreased over time in both groups, showing no significant difference between the groups (Cohen d=0.3, 95% CI −0.1 to 0.6; P=.21). Intervention costs per participant were estimated at US $279 for the MyCourse group and US $74 for the control group. The mean societal costs were US $18,092 (SD 25,662) and US $23,496 (SD 34,327), respectively. The MyCourse group led to fewer gained quality-adjusted life years at lower societal costs in the cost-utility analysis. In the cost-effectiveness analysis, the MyCourse group led to a larger reduction in drinking units over time at lower societal costs (incremental cost-effectiveness ratio per reduced drink: US $ −1158, 95% CI −1609 to −781). Conclusions: At 6 months, alcohol use was reduced by approximately one-third in both groups, with no significant differences between the digital intervention MyCourse and a noninteractive web-based brochure. At 12 months, cost-effectiveness analyses showed that MyCourse led to a larger reduction in drinking units over time, at lower societal costs. The MyCourse group led to marginally fewer gained quality-adjusted life years, also at lower societal costs. Trial Registration: Netherlands Trial Register NTR6010; https://www.trialregister.nl/trial/5433 International Registered Report Identifier (IRRID): RR2-10.1186/s12885-018-4206-z SN - 1438-8871 UR - //www.mybigtv.com/2022/2/e30095 UR - https://doi.org/10.2196/30095 UR - http://www.ncbi.nlm.nih.gov/pubmed/35103605 DO - 10.2196/30095 ID - info:doi/10.2196/30095 ER -