TY - JOUR AU - Yu, Yi-Fang AU - Wu, hui - jiuan AU - Ku, Stephane Wen-Wei AU - Huang, Po-Hsien AU - Li, Chia-Wen AU - Huang, Poyao AU - Strong, Carol PY - 2021 DA - 2021/12/23 TI -无避孕套肛交与男性性行为中HIV暴露前预防使用和性行为的异质性特征:潜类别分析使用性爱日记数据在移动互联网应用地中海乔- J Res SP - e33877六世23 - 12 KW -移动应用KW -暴露前预防KW - PrEP KW -潜类别分析KW——与男性发生性关系的男性KW - MSM KW -避孕套KW -性爱日记KW -坚持KW - App KW -性KW -日记KW -性健康KW -艾滋病毒预防KW -台湾KW -风险KW - AB -背景:已经开发了新的创新技术，如移动应用程序，以提高接触前预防(PrEP)的依从性和使用性日志。移动应用程序的连续性减少了通常影响避孕套和预防使用报告的回忆偏差。然而，目前使用的移动应用程序都不是为事件驱动的PrEP用户设计的，而且很少有研究证明了性日记数据的潜在用途，以促进理解不同类型的性日记和PrEP使用之间的不同艾滋病毒风险。目的:我们的目的是鉴别异质性事件和PrEP使用的概况，并研究不同类型的性事件中无避孕套肛交的风险。方法:我们从台湾两家医疗中心招募了35名自2020年5月以来与男性发生性关系的成年男性，随访4个月。参与者在进行PrEP或愿意进行PrEP。他们被要求在移动应用程序上记录自己的性行为、PrEP使用情况和剂量方案，以提高他们的PrEP依从性。使用潜在分类分析来区分性事件和PrEP使用的概况。指标包括每次性行为的正确摄入PrEP，参与者的性姿势，伴侣的艾滋病毒状况和年龄。 Results: A total of 551 sex events were classified into three classes by latent class analysis: PrEP nonadherent flip-flopping (234/551, 42%), PrEP imperfect-adherent power bottoming (284/551, 52%), and PrEP adherent serodiscordant topping (33/551, 6%). “PrEP nonadherent flip-flopping” sex events were more likely to involve condomless anal sex than “PrEP imperfect-adherent power bottoming” (OR 1.83, 95% CI 1.03-3.25) after considering random intercepts for individuals, and this class needed to increase their PrEP adherence and use of condoms. “PrEP imperfect-adherent power bottoming” realized their own risk and packaged PrEP with condoms to protect themselves. Up to 99% (32/33) of sex events in “PrEP adherent serodiscordant topping” were protected by PrEP, but all of the sex events in this group were condomless. Conclusions: Using the sex diary data could advance the capacity to identify high-risk groups. HIV prevention strategy should be more flexible and combine PrEP with condom use for future HIV prevention. SN - 1438-8871 UR - //www.mybigtv.com/2021/12/e33877 UR - https://doi.org/10.2196/33877 UR - http://www.ncbi.nlm.nih.gov/pubmed/34941560 DO - 10.2196/33877 ID - info:doi/10.2196/33877 ER -