李婷婷，郭怡然，郝红艳，郝曾雅，郝曾成波，郝曾昱，郝曾宇，郝朱汉喜，郝乔梦婷，郝乔嘉莹，郝蔡佳莹，郝李卫平，郝凌华，龚皮- 2021 DA - 2021/11/9 TI -羞耻感和抑郁症状在社交媒体干预下改善HIV感染者长期生活质量的中介作用:随机对照试验的二次分析研究背景:移动健康(mHealth)干预措施已被证明可有效改善艾滋病毒感染者的生活质量(QOL)。然而，人们对移动医疗干预的长期影响知之甚少。目的:本研究旨在探讨基于社交媒体的干预措施Run4Love对HIV感染者生活质量的干预机制，为期9个月的随访。方法:我们从中国南方的一家HIV门诊招募了同时经历抑郁症状升高的HIV感染者。共有300名符合条件的参与者在提供知情同意并完成基线调查后，按1:1的比例随机分为干预组和对照组。干预组接受为期3个月的基于微信的干预，包括认知行为压力管理(CBSM)课程和体育活动促进。对照组除了接受常规的艾滋病毒治疗护理外，还收到了一份关于营养指南的印刷小册子。参与者和研究人员都没有对小组分配一无所知。随访时间分别为3、6、9个月。 The primary outcome was depressive symptoms. Structural equation model (SEM) with longitudinal data was conducted to examine the sequential mediating effects of HIV-related stigma and depressive symptoms on the long-term intervention effects on participants’ QOL. Results: About 91.3% (274/300), 88.3% (265/300), and 86.7% (260/300) of all participants completed follow-up surveys at 3, 6, and 9 months, respectively. Results showed that the intervention had significantly improved participants' QOL at 9 months, via complete mediating effects of reduced HIV-related stigma at 3 months and decreased depressive symptoms at 6 months. No adverse events were reported. Conclusions: These findings underscore the critical roles of HIV-related stigma and depressive symptoms in an mHealth intervention with long-term effects on QOL improvements. We call for targeted mHealth interventions to improve QOL among people living with HIV, especially social media–based interventions that can address HIV-related stigma and alleviate depressive symptoms. Trial Registration: Chinese Clinical Trial Registry ChiCTR-IPR-17012606; https://www.chictr.org.cn/showproj.aspx?proj=21019 SN - 1438-8871 UR - //www.mybigtv.com/2021/11/e27897 UR - https://doi.org/10.2196/27897 UR - http://www.ncbi.nlm.nih.gov/pubmed/34751654 DO - 10.2196/27897 ID - info:doi/10.2196/27897 ER -