TY -的盟Roomi索盟——Ullah Waqas AU -艾哈迈德Faizan盟——Farooq Soban盟——Sadiq,奥萨马盟——Chohan Asad盟的魔法师,Munnam盟——Saddique Maryum AU -卡纳尔Shristi AU -沃森,罗伯特•AU -博尔冈玛戈特PY - 2020 DA - 2020/9/1 TI -羟氯喹的功效和叫COVID-19患者:单中心回顾性的图表总结乔- J地中海互联网Res SP - e21758六世- 22 - 9千瓦COVID-19 KW -羟氯喹KW -叫AB -背景:在COVID-19大流行的最初阶段，围绕使用羟氯喹(HCQ)和托珠单抗(TCZ)出现了毫无根据的狂热;然而，关于其有效性和安全性的证据一直存在争议。目的:本研究的目的是评价HCQ和TCZ在COVID-19患者中的整体临床疗效。我们假设，在这些患者中使用HCQ和TCZ将与住院死亡率的降低、升级到重症监护、有创机械通气或需要透析的急性肾衰竭有关。方法:采用回顾性队列研究确定HCQ和TCZ使用对住院期间硬临床结局的影响。共纳入176例确诊的住院患者。患者分为两组:(1)HCQ组(n=144) vs no-HCQ组(n=32); (2) TCZ组(n=32) vs no-TCZ组(n=144)。平均年龄、基线合并症和住院期间使用的其他药物在所有组中分布均匀。分别进行独立t检验和多变量logistic回归分析，以95% ci计算平均差异和校正优势比。 Results: The unadjusted odds ratio for patients upgraded to a higher level of care (ie, intensive care unit) (OR 2.6, 95% CI 1.19-5.69; P=.003) and reductions in C-reactive protein (CRP) level on day 7 of hospitalization (21% vs 56%, OR 0.21, 95% CI 0.08-0.55; P=.002) were significantly higher in the TCZ group compared to the control group. There was no significant difference in the odds of in-hospital mortality, upgrade to intensive medical care, need for invasive mechanical ventilation, acute kidney failure necessitating dialysis, or discharge from the hospital after recovery in both the HCQ and TCZ groups compared to their respective control groups. Adjusted odds ratios controlled for baseline comorbidities and medications closely followed the unadjusted estimates. Conclusions: In this cohort of patients with COVID-19, neither HCQ nor TCZ offered a significant reduction in in-hospital mortality, upgrade to intensive medical care, invasive mechanical ventilation, or acute renal failure needing dialysis. These results are similar to the recently published preliminary results of the HCQ arm of the Recovery trial, which showed no clinical benefit from the use of HCQ in hospitalized patients with COVID-19 (the TCZ arm is ongoing). Double-blinded randomized controlled trials are needed to further evaluate the impact of these drugs in larger patient samples so that data-driven guidelines can be deduced to combat this global pandemic. SN - 1438-8871 UR - //www.mybigtv.com/2020/9/e21758 UR - https://doi.org/10.2196/21758 UR - http://www.ncbi.nlm.nih.gov/pubmed/32784192 DO - 10.2196/21758 ID - info:doi/10.2196/21758 ER -