TY -非盟的郭,燕盟——香港,Y艾丽西娅AU - Cai,被非盟-李,全部非盟-,Yuantao AU -乔,嘉荫盟——徐Zhimeng盟——张Hanxi盟——曾Chengbo盟——刘Cong AU -李Yiran盟——朱Mengting盟,曾于非盟- Penedo,弗兰克·J PY - 2020 DA - 2020/2/11 TI - WeChat-Based干预(Run4Love)对中国艾滋病毒携带者中抑郁症状:随机对照试验JO - J Med Internet Res SP - e16715 VL - 22 IS - 2 KW - HIV KW -抑郁KW - mHealth KW -微信KW -随机对照试验AB -背景:HIV感染者(PLWH)有较高的抑郁症状发生率。然而，针对这一弱势群体的有效心理健康干预措施寥寥无几。目的:本研究的目的是评估基于微信的干预措施Run4Love的疗效，在中国300名艾滋病毒和抑郁症(PLWHD)患者中进行随机对照试验。方法:我们从华南地区HIV门诊招募PLWH。根据流行病学研究中心抑郁量表(CES-D)对参与者进行筛查。得分在16分或以上的人有资格参加。共有300名符合条件的患者被纳入研究。在获得参与者的知情同意、完成基线调查并收集参与者的头发样本以测量皮质醇后，参与者按1:1的比例被随机分配到干预组或对照组。干预组接受了通过流行社交媒体应用微信提供的Run4Love计划。 Cognitive behavioral stress management courses and weekly reminders of exercise were delivered in a multimedia format. Participants’ progress was monitored with timely and tailored feedback. The control group received usual care and a brochure on nutrition for PLWH. Data were collected at 3, 6, and 9 months. The primary outcome was depression, which was measured by a validated instrument. Results: Participants in the intervention and control groups were comparable at baseline; about 91.3% (139/150), 88.3% (132/150), and 86.7% (130/150) participants completed the 3-, 6-, and 9-month follow-ups, respectively. At the 3-month follow-up, a significant reduction in CES-D score was observed in the intervention group (from 23.9 to 17.7 vs from 24.3 to 23.8; mean difference=−5.77, 95% CI −7.82 to −3.71; P<.001; standard effect size d=0.66). The mean changes in CES-D score from baseline to the 6- and 9-month follow-ups between the two groups remained statistically significant. No adverse events were reported. Conclusions: The WeChat-based mobile health (mHealth) intervention Run4Love significantly reduced depressive symptoms among PLWHD, and the effect was sustained. An app-based mHealth intervention could provide a feasible therapeutic option for many PLWHD in resource-limited settings. Further research is needed to assess generalizability and cost-effectiveness of this intervention. Trial Registration: Chinese Clinical Trial Registry ChiCTR-IPR-17012606; http://www.chictr.org.cn/showproj.aspx?proj=21019 (Archived by WebCite at https://www.webcitation.org/78Bw2vouF) SN - 1438-8871 UR - //www.mybigtv.com/2020/2/e16715 UR - https://doi.org/10.2196/16715 DO - 10.2196/16715 ID - info:doi/10.2196/16715 ER -