TY - JOUR AU - Christensen, Helen AU - Batterham, Philip AU - Mackinnon, Andrew AU - Griffiths, Kathleen M AU - Kalia Hehir, Kanupriya AU - Kenardy, Justin AU - Gosling, John AU - Bennett, Kylie PY - 2014 DA - 2014/09/02 TI -使用网络干预预防广泛性焦虑障碍，iChill:背景:广泛性焦虑障碍(Generalized anxiety Disorder, GAD)是一种高患病率的慢性疾病。基于web的干预是可接受的、引人入胜的，并且可以大规模地交付。很少有随机对照试验评估焦虑预防项目的有效性，或提高有效性和参与度的因素。目的:本研究的目的是评估一个基于网络的项目在预防年轻人广泛性焦虑症症状方面的有效性，并确定电话和电子邮件提醒的作用。方法:通过澳大利亚选举名册招募的558名社区互联网用户进行了一项5组随机对照试验，随访6个月和12个月。在10周的时间里，进行了5次干预。第一组(活跃网站)接受心理教育、互联网认知行为疗法(ICBT)的联合干预，以缓解焦虑、促进身体活动和放松。第二组(带电话的活跃网站)收到了相同的网络程序和每周的电话提醒电话。第三组(有电子邮件的活跃网站)收到了相同的网络程序和每周的电子邮件提醒。 Group 4 (Control) received a placebo website. Group 5 (Control with telephone) received the placebo website plus telephone calls. Main outcome measures were severity of anxiety symptoms as measured by the GAD 7-item scale (GAD-7) (at post-test, 6, and 12 months). Secondary measures were GAD caseness, measured by the Mini International Neuropsychiatric Interview (MINI) at 6 months, Centre for Epidemiologic Studies-Depression scale (CES-D), Anxiety Sensitivity Index (ASI), Penn State Worry Questionnaire (PSWQ), and Days out of Role. Results: GAD-7 symptoms reduced over post-test, 6-month, and 12-month follow-up. There were no significant differences between Group 4 (Control) and Groups 1 (Active website), 2 (Active website with telephone), 3 (Active website with email), or 5 (Control with telephone) at any follow-up. A total of 16 cases of GAD were identified at 6 months, comprising 6.7% (11/165) from the Active groups (1, 2, 3) and 4.5% (5/110) from the Control groups (4, 5), a difference that was not significant. CES-D, ASI, and PSWQ scores were significantly lower for the active website with email reminders at post-test, relative to the control website condition. Conclusions: Indicated prevention of GAD was not effective in reducing anxiety levels, measured by GAD-7. There were significant secondary effects for anxiety sensitivity, worry, and depression. Challenges for indicated prevention trials are discussed. Trial Registration: International Standard Randomized Controlled Trial Number (ISRCTN): 76298775; http://www.controlled-trials.com/ISRCTN76298775 (Archived by WebCite at http://www.webcitation.org/6S9aB5MAq). SN - 1438-8871 UR - //www.mybigtv.com/2014/9/e199/ UR - https://doi.org/10.2196/jmir.3507 UR - http://www.ncbi.nlm.nih.gov/pubmed/25270886 DO - 10.2196/jmir.3507 ID - info:doi/10.2196/jmir.3507 ER -