TY - JOUR AU - McNaughton, Emily C AU - Coplan, Paul M AU - Black, Ryan A AU - Weber, Sarah E AU - Chilcoat, Howard D AU - Butler，Stephen F PY - 2014 DA - 2014/05/02 TI -监测网络论坛来评估反应引入新配方好阻止滥用乔- J地中海互联网Res SP - e119六世- 16 - 5 KW -互联网KW -阿片类药物镇痛KW -药物滥用KW -处方药KW -好KW -流行病学KW -监视KW -社会媒体KW -定性研究AB -背景:申论,阻止滥用阿片类止痛药是一种方法对提高其平衡。为了评估难以接触到的处方药滥用人群的情绪和击败这些产品的尝试，评估互联网论坛上关于重新配方产品的帖子可能是有用的。一种重新配制的奥施康定(缓释羟考酮)，具有阻止滥用的物理化学性质，提供了一个评估在线讨论中关于重新配制的帖子的机会。目的:本研究的目的是利用互联网论坛上的信息来评估对重新配制的奥施康定的引入的反应，并确定旨在击败该产品的滥用威慑特性的方法。方法:从2008年1月1日至2013年9月30日的7个论坛收集的帖子，在2010年8月9日重新配方奥施康定引入之前和之后进行评估。对整个研究期间的讨论水平进行了定量评估，并对奥施康定和2个比较者在奥施康定重新配方前后26个月的帖子内容进行了定性编码。估计每种产品在重新配方前后的产品背书率，即支持与劝阻帖子的比值(ERo)。还计算了每种产品在引入前后的ERos(即ERos比率)的变化。此外，从2010年8月9日到2013年9月，对与击败重新配制的奥施康定配方有关的帖子内容进行了评估。 Results: Over the study period, 45,936 posts related to OxyContin, 18,685 to Vicodin (hydrocodone), and 23,863 to Dilaudid (hydromorphone) were identified. The proportion of OxyContin-related posts fluctuated between 6.35 and 8.25 posts per 1000 posts before the reformulation, increased to 10.76 in Q3 2010 when reformulated OxyContin was introduced, and decreased from 9.14 in Q4 2010 to 3.46 in Q3 2013 in the period following the reformulation. The sentiment profile for OxyContin changed following reformulation; the post-to-preintroduction change in the ERo indicated reformulated OxyContin was discouraged significantly more than the original formulation (ratio of ERos=0.43, P<.001). A total of 37 recipes for circumventing the abuse-deterrent characteristics of reformulated OxyContin were observed; 32 were deemed feasible (ie, able to abuse). The frequency of posts reporting abuse of reformulated OxyContin via these recipes was low and decreased over time. Among the 5677 posts mentioning reformulated OxyContin, 825 posts discussed recipes and 498 reported abuse of reformulated OxyContin by such recipes (41 reported injecting and 128 reported snorting). Conclusions: After introduction of physicochemical properties to deter abuse, changes in discussion of OxyContin on forums occurred reflected by a reduction in discussion levels and endorsing content. Despite discussion of recipes, there is a relatively small proportion of reported abuse of reformulated OxyContin via recipes, particularly by injecting or snorting routes. Analysis of Internet discussion is a valuable tool for monitoring the impact of abuse-deterrent formulations. SN - 14388871 UR - //www.mybigtv.com/2014/5/e119/ UR - https://doi.org/10.2196/jmir.3397 UR - http://www.ncbi.nlm.nih.gov/pubmed/24800858 DO - 10.2196/jmir.3397 ID - info:doi/10.2196/jmir.3397 ER -