TY - JOUR AU - Bolier, Linda AU - Haverman, Merel AU - Kramer, Jeannet AU - Westerhof, Gerben J AU - Riper, Heleen AU - Walburg, Jan A AU - Boon, Brigitte AU - Bohlmeijer, Ernst PY - 2013 DA - 2013/09/16 TI -基于互联网的促进轻度抑郁症成年人心理健康的干预:随机对照试验JO - J Med Internet Res SP - e200vl - 15is - 9kw -公共卫生KW -预防KW -抑郁KW -福祉KW -随机对照试验KW -互联网AB -背景:抑郁症是一个全球性问题，需要全球解决方案来解决它。提高幸福感本身就有好处，可能是预防抑郁症的好策略。通过互联网提供健康干预可能会产生协同效应。Psyfit(“在线心理健康”)是一种基于积极心理学的全自动自助干预，旨在改善幸福感。本研究探讨了这种干预的临床效果。方法:我们进行了一项两组随机对照试验，比较了使用Psyfit 2个月(n=143)与等待名单对照条件(n=141)的影响。研究招募了一般人群中轻度至中度抑郁、寻求自我帮助的成年人。主要终点为心理健康连续简表(MHC-SF)和世界卫生组织幸福指数(WHO-5);次要结局为抑郁症状、焦虑、活力和一般健康，分别由流行病学研究中心抑郁量表(CES-D)、医院焦虑和抑郁量表焦虑子量表(HADS-A)和医疗结局研究简表(MOS-SF)活力和一般健康子量表测量。 Online measurements were taken at baseline, 2 months, and 6 months after baseline. Results: The dropout rate was 37.8% in the Psyfit group and 22.7% in the control group. At 2-month follow-up, Psyfit tended to be more effective in enhancing well-being (nonsignificantly for MHC-SF: Cohen’s d=0.27, P=.06; significantly for WHO-5: Cohen’s d=0.31, P=.01), compared to the waiting-list control group. For the secondary outcomes, small but significant effects were found for general health (Cohen’s d=0.14, P=.01), vitality (d=0.22, P=.02), anxiety symptoms (Cohen’s d=0.32, P=.001), and depressive symptoms (Cohen’s d=0.36, P=.02). At 6-month follow-up, there were no significant effects on well-being (MHC-SF: Cohen’s d=0.01, P=.90; WHO-5: Cohen’s d=0.26, P=.11), whereas depressive symptoms (Cohen’s d=0.35, P=.02) and anxiety symptoms (Cohen’s d=0.35, P=.001) were still significantly reduced compared to the control group. There was no clear dose–response relationship between adherence and effectiveness, although some significant differences appeared across most outcomes in favor of those completing at least 1 lesson in the intervention. Conclusions: This study shows that an online well-being intervention can effectively enhance well-being (at least in the short-term and for 1 well-being measure) and can help to reduce anxiety and depression symptoms. Further research should focus on increasing adherence and motivation, reaching and serving lower-educated people, and widening the target group to include people with different levels of depressive symptoms. Trial Registration: Netherlands Trial Register (NTR) number: NTR2126; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2126 (archived by WebCite at http://www.webcitation.org/6IIiVrLcO). SN - 14388871 UR - //www.mybigtv.com/2013/9/e200/ UR - https://doi.org/10.2196/jmir.2603 UR - http://www.ncbi.nlm.nih.gov/pubmed/24041479 DO - 10.2196/jmir.2603 ID - info:doi/10.2196/jmir.2603 ER -