TY - JOUR AU - Hughes, Shannon AU - Cohen, David PY - 2011 DA - 2011/07/29 TI -在线消费者对药物知识有帮助吗?JO - J Med Internet Res SP - e53 VL - 13 IS - 3kw -精神药物KW -精神健康KW -消费者健康信息KW -互联网KW -药物流行病学KW -药物监测KW -产品监测，上市后AB -背景:正在进行的在线健康搜索过滤计划将消费者生成的内容排除在搜索结果之外，尽管与专业人员控制的内容相比，它的劣势并没有被证明。抗抑郁药艾司西酞普兰和抗精神病药喹硫平在过去5年里都是各自类别药物中最畅销的药物。这两种药物都有不同的标示外心理健康和非心理健康用途，从缓解失眠和偏头痛到治疗严重发育障碍。目的:我们的目的是描述在线消费者评论中最常报告的艾司西酞普兰和喹硫平的效果，将它们与专业控制的商业健康网站描述的效果进行比较，并衡量在线消费者药物评论的可用性。方法:分层简单随机抽样，从2个消费者生成(www.askapatient.com和www.crazymeds.us)和2个专业控制(www.webmd.com和www.revolutionhealth.com)的健康网站对两种药物的6998个消费者评论中选择960个消费者评论。专业药物描述包括后两个网站上所有药物的标准信息。所有文本数据都对药物效果进行归纳编码，并评估编码器之间的一致性。卡方用于检验消费者报告的效果和网站起源之间的关联。 Results: Consumers taking either escitalopram (n = 480) or quetiapine (n = 480) most frequently reported symptom improvement (30.4% or 146/480, 24.8% or 119/480) or symptom worsening (15.8% or 76/480, 10.2% or 49/480), changes in sleep (36% or 173/480, 60.6% or 291/480) and changes in weight and appetite (22.5% or 108/480, 30.8% or 148/480). More consumers posting reviews on consumer-generated rather than professionally controlled websites reported symptom worsening on quetiapine (17.3% or 38/220 versus 5% or 11/220, P < .001), while more consumers posting on professionally controlled websites reported symptom improvement (32.7% or 72/220 versus 21.4% or 47/220, P = .008). Professional descriptions more frequently listed physical adverse effects and warnings about suicidal ideation while consumer reviews emphasized effects disrupting daily routines and provided richer descriptions of effects in context. The most recent 20 consumer reviews on each drug from each website (n = 80) were comparable to the full sample of reviews in the frequency of commonly reported effects. Conclusion: Consumer reviews and professional medication descriptions generally reported similar effects of two psychotropic medications but differed in their descriptions and in frequency of reporting. Professional medication descriptions offer the advantage of a concise yet comprehensive listing of drug effects, while consumer reviews offer greater context and situational examples of how effects may manifest in various combinations and to varying degrees. The dispersion of consumer reviews across websites limits their integration, but a brief browsing strategy on the two target medications nonetheless retrieved representative consumer content. Current strategies for filtering online health searches to return only trusted or approved websites may inappropriately address the challenge to identify quality health sources on the Internet because such strategies unduly limit access to an entire complementary source for health information. SN - 1438-8871 UR - //www.mybigtv.com/2011/3/e53/ UR - https://doi.org/10.2196/jmir.1716 UR - http://www.ncbi.nlm.nih.gov/pubmed/21807607 DO - 10.2196/jmir.1716 ID - info:doi/10.2196/jmir.1716 ER -