TY -的AU -迈耶,Bjorn AU -伯杰,托马斯AU -卡斯帕,弗朗茨AU - Beevers,克里斯托弗·G AU -安德森,格哈德盟-维斯,马里奥PY - 2009 DA - 2009/5/11 TI -小说在线综合治疗抑郁症的有效性(Deprexis):随机对照试验乔- J地中海互联网Res SP e15六世- 11 - 2 AB -背景:抑郁症与巨大痛苦和成本有关,和许多病人接受治疗不足,常常因为有限的可用性的治疗。基于网络的治疗可能在弥合供需差距方面发挥越来越重要的作用。我们开发了综合的、基于网络的项目Deprexis，它涵盖了诸如行为激活、认知重组、正念/接受练习和社交技能训练等治疗方法。目的:评价网络干预在随机对照试验中的有效性。方法:在德国，通过网络抑郁论坛招募了396名成人，他们按照80:20加权随机顺序被随机分配到9周的即时程序访问作为常规治疗的附加条件(N = 320)，或9周的延迟访问+常规治疗条件(N = 76)。在治疗前、治疗后和6个月随访时，我们以抑郁(贝克抑郁量表)作为主要结局指标，以社会功能(工作和社会适应量表)作为次要结局指标。完成者分析和意向治疗分析。结果:396名参与者中，216人(55%)在9周后完成测量。现有病例分析显示抑郁严重程度(BDI)显著降低，Cohen 's d = 0.64 (CI 95% = 0.33 - 0.94)，社会功能(WSA)显著改善，Cohen 's d = 0.64, 95% (CI 95% = 0.33 - 0.95)。在6个月的随访中，这些改善得以维持。 Intention-to-treat analyses confirmed significant effects on depression and social functioning improvements (BDI: Cohen’s d = .30, CI 95% = 0.05 - 0.55; WSA: Cohen’s d = .36, CI 95% = 0.10 - 0.61). Moreover, a much higher percentage of patients in the intervention group experienced a significant reduction of depression symptoms (BDI: odds ratio [OR] = 6.8, CI 95% = 2.90 - 18.19) and recovered more often (OR = 17.3, 95% CI 2.3 - 130). More than 80% of the users felt subjectively that the program had been helpful. Conclusions: This integrative, Web-based intervention was effective in reducing symptoms of depression and in improving social functioning. Findings suggest that the program could serve as an adjunctive or stand-alone treatment tool for patients suffering from symptoms of depression. Trial Registration: International Standard Randomized Controlled Trial Number (ISRCTN): 64953693; http://www.controlled-trials.com/ISRCTN64953693/64953693 (Archived by WebCite at http://www.webcitation.org/5ggzvTJPD) SN - 1438-8871 UR - //www.mybigtv.com/2009/2/e15/ UR - https://doi.org/10.2196/jmir.1151 UR - http://www.ncbi.nlm.nih.gov/pubmed/19632969 DO - 10.2196/jmir.1151 ID - info:doi/10.2196/jmir.1151 ER -