一个以患者为中心的沟通，由药剂师领导的基于web的药物坚持工具的有效性卡塔尔世界杯8强波胆分析:一项聚类随机对照试验的结果% a van Lieshout,Jan % a Lacroix,Joyca % a van Halteren,Aart % a Teichert,Martina %+医疗质量科学中心，内梅亨大学医学中心内梅亨健康科学研究所，邮箱9101,Nijmegen, 6500HB，荷兰，31 024 361 53 05，jan.vanlieshout@radboudumc.nl %K药物依从性%K改善%K干预%K基于网络的%K定制干预%K以患者为中心的%K障碍%K初级保健%K心血管疾病%K糖尿病%D 2022 %7 7.4.2022 %9原始论文%J J医学互联网Res %G英语%X背景:越来越多的人使用药物治疗慢性疾病;不坚持治疗很常见，导致疾病控制不良。一种基于网络的工具可以识别与相关的潜在个体障碍有关的不依从性风险增加，从而促进量身定制的干预措施和改善依从性。目的:本研究旨在评估一种新开发的工具的有效性，旨在提高药物依从性。方法:我们对开始服用心血管或口服降糖药物的患者进行了一组随机对照试验。参与者是从社区药店招募的。他们完成了一份在线问卷，其中包括对他们不坚持用药的风险和随后坚持用药的障碍的评估。在干预组的药店，药剂师和非依从性风险高的患者在面对面的会议上讨论了在药片上显示的个人障碍，并与他们的全科医生和执业护士分享。 Tailored interventions were initiated by pharmacists. Barriers of control patients were not presented nor discussed and these patients received usual care. The primary outcome was the effectiveness of the intervention on medication adherence at 8 months’ follow-up between patients with an increased nonadherence risk from the intervention and control groups, calculated from dispensing data. Results: Data from 492 participants in 15 community pharmacies were available for analyses (intervention 253, 7 pharmacies; control 239, 8 pharmacies). The intervention had no effect on medication adherence (B=–0.01; 95% CI –0.59 to 0.57; P=.96), nor in the post hoc per-protocol analysis (B=0.19; 95% CI –0.50 to 0.89; P=.58). Conclusions: This study showed no effectiveness of a risk stratification and tailored intervention addressing personal barriers for medication adherence. Various potential explanations for lack of effectiveness were identified. These explanations relate, for instance, to high medication adherence in the control group, study power, and fidelity. Process evaluation should elicit possible improvements and inform the redesign of intervention and implementation. Trial Registration: The Netherlands National Trial Register NTR5186; https://tinyurl.com/5d8w99hk %M 35389359 %R 10.2196/16141 %U //www.mybigtv.com/2022/4/e16141 %U https://doi.org/10.2196/16141 %U http://www.ncbi.nlm.nih.gov/pubmed/35389359