基于载脂蛋白E基因型的基于web的轻度认知障碍干预效果:卡塔尔世界杯8强波胆分析半实验研究%A Tsolaki,Anthoula C %A Tsolaki,Magda %A Pandria,Niki %A Lazarou,Eftychia %A Gkatzima,Olymbia %A Zilidou,Vasiliki %A Karagianni,Maria %A Iakovidou-Kritsi,Zafiroula %A Kimiskidis,Vasilios K %A Bamidis,Panagiotis D %+医学物理实验室，亚里斯多德大学医学院，邮箱376，亚里斯多德大学医学院，希腊，塞萨洛尼基，30 2310999310，背景:载脂蛋白E (APOE) ε4等位基因是阿尔茨海默病和轻度认知障碍(MCI)的主要遗传危险因素。基于计算机的培训项目可以提高老年人的认知能力。然而，基于计算机的干预对MCI APOE ε4载体的影响从未被研究过。目的:研究不同网络干预的效果和载脂蛋白e亚型特异性差异对训练结果的影响。方法:采用准实验研究设计，202名60岁及以上的MCI患者通过创新的信息和通信技术锻炼游戏平台参加了三种不同的干预方案(身体和认知[持久记忆，或LLM]，认知[主动控制，或AC]，或身体干预[体育训练控制，或PTC])。每个干预组的参与者被细分为载脂蛋白e ε4携带者和非载脂蛋白e ε4携带者。所有参与者在训练前后都进行了广泛的神经心理学评估、血液测试和大脑成像。结果:所有的干预都在干预后产生了多个具有统计学意义的认知益处。 Verbal learning (California Verbal Learning Test: immediate recall test score—LLM: P=.04; AC: P<.001), working memory (digit span forward and backward test scores—AC: P=.03; PTC: P=.02 and P=.006, respectively), and long-term memory (California Verbal Learning Test: delayed recall test score—LLM: P=.02; AC: P=.002; and PTC: P=.02) were improved. There was no statistically significant difference among the intervention effects. APOE ε4 presence moderates intervention effects as the LLM intervention improved only their task-switching processing speed (Trail Making Test, Part B: P=.03) and the PTC intervention improved only the working memory (digit span backward: P=.03). No significant performance alteration was noted for the APOE ε4+ cognitive AC training group. Conclusions: None of the applied interventions could be identified as the optimal one; it is suggested, however, that combined cognitive and physical training and physical training via exergaming may be more effective for the high-risk MCI ΑPOE ε4+ subgroup. %M 32379048 %R 10.2196/14617 %U //www.mybigtv.com/2020/5/e14617 %U https://doi.org/10.2196/14617 %U http://www.ncbi.nlm.nih.gov/pubmed/32379048