一种基于web的自我滴定程序来控制原发性高血压患者的血压:卡塔尔世界杯8强波胆分析随机对照试验%高A，陈志文，陈廷宇%程淑明，林淑明，张伟翔%张跃存%+三科综合医院护理部，台北市成功路二段325号，114，台湾，886 2 87923311 ext 17359, chiwenkao@ndmctsgh.edu.tw %K网络%K自我定量%K血压%K高血压%K健康相关生活质量%D 2019 %7 5.12.2019 %9原论文%J J医学互联网Res %G英文%X背景:高血压是心脏、血管和肾脏疾病死亡的主要原因。有效控制血压升高已被证明可以减少靶器官损伤。基于网络的自我滴定计划可能使患者能够控制自己的疾病，分享抗高血压剂量滴定的决定，并改善自我管理，最终改善与健康相关的生活质量。目的:我们的主要目的是评估基于网络的自我滴定程序对改善原发性高血压患者血压控制的效果。我们的第二个目标是评估该方案对改善与健康相关的生活质量的影响。方法:这是一项平行组、双盲、随机对照试验，在基线、3个月和6个月进行评估。研究对象为台湾北部某心脏病门诊部的原发性高血压患者(血压>130/80 mm Hg)，随机分为干预组和对照组。干预组接受基于网络的自我滴定程序，而对照组接受常规护理。 The random allocation was concealed from participants and outcome evaluators. Health-related quality of life was measured by the EuroQol five-dimension self-report questionnaire. We used generalized estimating equations to evaluate the effects of the intervention. Results: We included 222 patients and divided them equally into intervention (n=111) and control (n=111) groups. Patients receiving the Web-based self-titration program showed significantly greater improvement in the systolic and diastolic blood pressure control than those who did not receive this program, at 3 months (–21.4 mm Hg and –5.4 mm Hg, respectively; P<.001) and 6 months (–27.8 mm Hg and –9.7 mm Hg, respectively; P<.001). Compared with the control group, the intervention group showed a significant decrease in the overall defined daily dose at both 3 (–0.202, P=.003) and 6 (–0.236, P=.001) months. Finally, health-related quality of life improved significantly in the intervention group compared with the control group at both 3 and 6 months (both, P<.001). Conclusions: A Web-based self-titration program can provide immediate feedback to patients about how to control their blood pressure and manage their disease at home. This program not only decreases mean blood pressure but also increases health-related quality of life in patients with primary hypertension. Trial Registration: ClinicalTrials.gov NCT03470974; https://clinicaltrials.gov/ct2/show/NCT03470974 %M 31804186 %R 10.2196/15836 %U //www.mybigtv.com/2019/12/e15836 %U https://doi.org/10.2196/15836 %U http://www.ncbi.nlm.nih.gov/pubmed/31804186