期刊文章I JMIR出版物在线干预比较极低碳水化合物生酮饮食和生活方式卡塔尔世界杯8强波胆分析建议与2型糖尿病超重个体的盘子法饮食:一项随机对照试验%A Saslow,Laura R %A Mason,Ashley E %A Kim,Sarah %A Goldman,Veronica %A Ploutz-Snyder,Robert %A Bayandorian,Hovig %A Daubenmier,Jennifer %A Hecht,Frederick M %A Moskowitz,Judith T %+密歇根大学护理学院健康行为和生物科学系，室2178,400 N Ingalls St，密歇根州，48105，美国，1 734 764 7836，saslowl@umich.edu %K eHealth %K饮食%K体重减轻%K 2型糖尿病%D 2017 %7 13.02.2017 %9原论文%J J医学互联网Res %G英文%X背景:2型糖尿病是一种流行的慢性病，饮食是治疗的一个组成部分。在我们之前的试验中，我们发现，建议遵循极低碳水化合物生酮饮食和改变生活方式因素(体育活动、睡眠、积极的影响、专注力)有助于超重的2型糖尿病或前驱糖尿病患者改善血糖控制和减肥。这是一次面对面的干预，对于没有时间、灵活性、交通工具、社会支持和/或经济资源的人来说，这可能是一个障碍。目的:目的是确定基于我们之前的建议(自由选择极低碳水化合物生酮饮食与生活方式因素;“干预”)或基于美国糖尿病协会“创建你的餐盘”(“控制”)的在线饮食计划，将改善2型糖尿病超重患者的血糖控制和其他健康结果。方法:在这项试点可行性研究中，我们随机选择2型糖尿病(糖化血红蛋白[HbA1c] 6.5 -9.0%)的超重成人(体重指数≥25)，根据我们之前的建议(n=12)或基于盘子法饮食的在线饮食计划(n=13)进行32周的在线干预，以评估每种干预对血糖控制和其他健康结果的影响。采用混合效应线性回归分析主、次转归，比较各组转归。结果:在32周时，干预组参与者降低糖化血红蛋白水平(估计边际平均值[EMM] -0.8%， 95% CI -1.1%至-0.6%)高于对照组(EMM -0.3%， 95% CI -0.6%至0.0%; P=.002). More than half of the participants in the intervention group (6/11, 55%) lowered their HbA1c to less than 6.5% versus 0% (0/8) in the control group (P=.02). Participants in the intervention group lost more weight (EMM –12.7 kg, 95% CI –16.1 to –9.2 kg) than participants in the control group (EMM –3.0 kg, 95% CI –7.3 to 1.3 kg; P<.001). A greater percentage of participants lost at least 5% of their body weight in the intervention (10/11, 90%) versus the control group (2/8, 29%; P=.01). Participants in the intervention group lowered their triglyceride levels (EMM –60.1 mg/dL, 95% CI –91.3 to –28.9 mg/dL) more than participants in the control group (EMM –6.2 mg/dL, 95% CI –46.0 to 33.6 mg/dL; P=.01). Dropout was 8% (1/12) and 46% (6/13) for the intervention and control groups, respectively (P=.07). Conclusions: Individuals with type 2 diabetes improved their glycemic control and lost more weight after being randomized to a very low-carbohydrate ketogenic diet and lifestyle online program rather than a conventional, low-fat diabetes diet online program. Thus, the online delivery of these very low-carbohydrate ketogenic diet and lifestyle recommendations may allow them to have a wider reach in the successful self-management of type 2 diabetes. Trial Registration: ClinicalTrials.gov NCT01967992; https://clinicaltrials.gov/ct2/show/NCT01967992 (Archived by WebCite at http://www.webcitation.org/6o0fI9Mkq) %M 28193599 %R 10.2196/jmir.5806 %U //www.mybigtv.com/2017/2/e36/ %U https://doi.org/10.2196/jmir.5806 %U http://www.ncbi.nlm.nih.gov/pubmed/28193599