杂志文章@ 14388871 % JMIR出版公司在移动健康认知刺激卡塔尔世界杯8强波胆分析计划后，酗酒者的执行功能:随机对照试验%A Gamito,Pedro %A Oliveira,Jorge %A Lopes,Paulo %A Brito,Rodrigo %A Morais,Diogo %A Silva,Diana %A Silva,Ana %A Rebelo,Sara %A Bastos,Marta %A Deus,Alberto %+葡语人文科技大学，坎波格兰德，376，里斯本，1749 - 024，葡萄牙，351 217 515 500，pedro.gamito@ulusofona.pt %K酒精%K成瘾%K认知刺激%K执行功能%K移动健康%K严重游戏%D 2014 %7 17.04.2014 %9原始论文%J J医学互联网Res %G英语%X背景:酒精依赖的后果是严重的，可能从身体疾病到几个认知领域的神经心理缺陷。酒精滥用也与大脑功能障碍有关，特别是前额叶皮层。传统的神经心理干预(纸笔认知刺激训练)有积极的效果，但耗时、昂贵，对患者没有激励作用。目的:我们的目标是测试一种使用移动技术和严肃游戏的神经心理干预新方法对酒精依赖患者的认知效果。方法:试验设计包括两组研究，评估在接受酒精依赖综合征治疗的患者中，使用移动严肃游戏(mHealth)进行神经心理学干预与对照组(正常治疗，无神经心理学干预)的认知结果。68名患者从一家酒精康复诊所招募，并随机分配到移动健康组(n=33)或对照组(n=35)。实验组的干预包括治疗师辅助的认知刺激疗法，为期4周，每周2-3天。结果:14例患者退出研究。 The results of the neuropsychological assessments with the remaining 54 patients showed an overall increase (P<.05) of general cognitive abilities, mental flexibility, psychomotor processing speed, and attentional ability in both experimental (n=26) and control groups (n=28). However, there was a more pronounced improvement (P=.01) specifically in frontal lobe functions from baseline (mean 13.89, SE 0.58) to follow-up (mean 15.50, SE 0.46) in the experimental group but not in the control group. Conclusions: The overall increase in general cognitive function for both experimental and control groups supports the beneficial role of existing alcohol treatment protocols aimed at minimizing withdrawal symptoms, but the differential improvements observed in frontal lobe functioning supports the use of mobile serious games for neuropsychological stimulation to overcome executive dysfunction in patients with alcohol dependence. This trial was negative on two neuropsychological/cognitive tests, and positive on one. Trial Registration: ClinicalTrials.gov NCT01942954; http://www.clinicaltrials.gov/ct2/show/NCT01942954 (Archived by WebCite at http://www.webcitation.org/6OYDqHLwB). %M 24742381 %R 10.2196/jmir.2923 %U //www.mybigtv.com/2014/4/e102/ %U https://doi.org/10.2196/jmir.2923 %U http://www.ncbi.nlm.nih.gov/pubmed/24742381