提高青少年艾滋病毒感染者/艾滋病患者抗逆转录病毒治疗的依从性:使用个性化、交互式、每日短信提醒的初步研究A Dowshen,Nadia %A Kuhns,Lisa M %A Johnson,Amy %A Holoyda,Brian James %A Garofalo,Robert %+ Craig-Dalsimer青少年医学部，费城儿童医院，市场街3535号，1542室，宾夕法尼亚州费城，19104，美国，1 267 426 2591，dowshenn@email.chop.edu %K青少年%K艾滋病毒/艾滋病%K坚持不懈%K短信%K短消息服务%K短信%K移动健康干预%D 2012 %7 05.04.2012 %9原始论文%J J医学互联网Res %G英文%X背景:对于患有人类免疫缺陷病毒(HIV)/获得性免疫缺陷综合征(艾滋病)的青少年，不坚持抗逆转录病毒治疗(ART)可导致不良健康结果和显著降低预期寿命。目的:评价短信服务(SMS)或短信提醒提高青少年艾滋病毒/艾滋病抗逆转录病毒治疗依从性的可行性、可接受性和初步疗效。方法:我们从2009年到2010年在一个为感染艾滋病毒/艾滋病的青年提供临床服务的社区卫生中心进行了这项前瞻性试点研究。资格标准包括艾滋病毒血清阳性，年龄14-29岁，使用个人手机，英语能力，以及有记录的抗逆转录病毒治疗依从性差。在24周的研究期间，参与者每天都会收到个性化的短信提醒，并在1小时后收到一条跟踪消息，评估他们是否服用了药物，并要求参与者通过短信回复，如果他们服用了药物，则回复数字1，如果没有，则回复数字2。结果评价包括可行性、可接受性和依从性。使用视觉模拟量表(VAS)和艾滋病临床试验组(ACTG)问卷4天回忆来确定自我报告的依从性。在0周、12周和24周时，病毒载量和CD4细胞计数作为粘附性和疾病进展的生物标志物进行随访。 Results: Participants (N = 25) were mean age 23 (range 14–29) years, 92% (n = 23) male, 60% (n = 15) black, and 84% (n = 21) infected through unprotected sex. Mean VAS scores significantly increased at 12 and 24 weeks in comparison with baseline (week 0: 74.7, week 12: 93.3, P < .001; week 24: 93.1, P < .001). ACTG questionnaire 4-day recall also improved (week 0: 2.33, week 12: 3.24, P = .002; week 24: 3.19, P = .005). There was no significant difference in CD4 cell count or viral load between baseline and 12- or 24-week follow-up, although there was a trend toward improvement of these biomarkers and a small to moderate standardized effect size (range of Cohen d: –0.51 to 0.22). Of 25 participants, 21 (84%) were retained, and 20 of the 21 (95%) participants who completed the study found the intervention helpful to avoid missing doses. Conclusions: In this pilot study, personalized, interactive, daily SMS reminders were feasible and acceptable, and they significantly improved self-reported adherence. Larger controlled studies are needed to determine the impact of this intervention on ART adherence and other related health outcomes for youth living with HIV/AIDS. %M 22481246 %R 10.2196/jmir.2015 %U //www.mybigtv.com/2012/2/e51/ %U https://doi.org/10.2196/jmir.2015 %U http://www.ncbi.nlm.nih.gov/pubmed/22481246