%0期刊文章@ 1438- 8871% I Gunther Eysenbach %V 13% N 3% P e53% T在线消费者可以为药物知识做出贡献吗?A Hughes,Shannon %A Cohen,David %+犹他州立大学社会学、社会工作和人类学系，0730 Old Main, 240A室，Logan, UT, 84322，美国，1 435 797 8636,shughes5@msn.com %K精神药物%K精神健康%K消费者健康信息%K互联网%K药物流行病学%K药物监测%K产品监测，背景:正在进行的过滤在线健康搜索的举措将消费者生成的内容从搜索返回中排除，尽管与专业控制的内容相比，其劣势并未得到证明。抗抑郁药艾司西酞普兰和抗精神病药喹硫平在过去5年里分别成为各自药物类别中最畅销的药物。这两种药物都有多种标示外的精神健康和非精神健康用途，从缓解失眠和偏头痛到治疗严重的发育障碍。目的:我们的目的是描述在线消费者评论中最常报告的艾司西酞普兰和奎硫平的效果，并将其与专业控制的商业健康网站中描述的效果进行比较，并评估在线消费者药物评论的可用性。方法:从2个消费者生成(www.askapatient.com和www.crazymeds.us)和2个专业控制(www.webmd.com和www.revolutionhealth.com)的2个健康网站上对这两种药物的6998个消费者评论中选择960个分层简单随机样本。专业药物描述包括后2个网站上关于药物的所有标准信息。所有文本数据都被归纳编码药物效果，并评估编码器之间的一致性。卡方被用来检验消费者报告的效果和网站来源之间的关联。 Results: Consumers taking either escitalopram (n = 480) or quetiapine (n = 480) most frequently reported symptom improvement (30.4% or 146/480, 24.8% or 119/480) or symptom worsening (15.8% or 76/480, 10.2% or 49/480), changes in sleep (36% or 173/480, 60.6% or 291/480) and changes in weight and appetite (22.5% or 108/480, 30.8% or 148/480). More consumers posting reviews on consumer-generated rather than professionally controlled websites reported symptom worsening on quetiapine (17.3% or 38/220 versus 5% or 11/220, P < .001), while more consumers posting on professionally controlled websites reported symptom improvement (32.7% or 72/220 versus 21.4% or 47/220, P = .008). Professional descriptions more frequently listed physical adverse effects and warnings about suicidal ideation while consumer reviews emphasized effects disrupting daily routines and provided richer descriptions of effects in context. The most recent 20 consumer reviews on each drug from each website (n = 80) were comparable to the full sample of reviews in the frequency of commonly reported effects. Conclusion: Consumer reviews and professional medication descriptions generally reported similar effects of two psychotropic medications but differed in their descriptions and in frequency of reporting. Professional medication descriptions offer the advantage of a concise yet comprehensive listing of drug effects, while consumer reviews offer greater context and situational examples of how effects may manifest in various combinations and to varying degrees. The dispersion of consumer reviews across websites limits their integration, but a brief browsing strategy on the two target medications nonetheless retrieved representative consumer content. Current strategies for filtering online health searches to return only trusted or approved websites may inappropriately address the challenge to identify quality health sources on the Internet because such strategies unduly limit access to an entire complementary source for health information. %M 21807607 %R 10.2196/jmir.1716 %U //www.mybigtv.com/2011/3/e53/ %U https://doi.org/10.2196/jmir.1716 %U http://www.ncbi.nlm.nih.gov/pubmed/21807607