@文章{信息:doi/10.2196/39741，作者=“Hesseldal, Laura和Christensen, Jeanette Reffstrup和Olesen, Thomas Bastholm和Olsen, Michael Hecht和Jakobsen, Pernille Ravn和Laursen, Ditte Hjorth和Lauridsen, J{\o} gen Trankj{\ae}r和Nielsen, Jesper Bo和S{\o} derard, Jens和Brandt, Carl Joakim”，标题=“初级保健中的长期减肥——以电子健康生活方式指导计划为基础”;随机对照试验”，期刊=“J Med Internet Res”，年=“2022”，月=“Sep”，日=“23”，卷=“24”，号=“9”，页=“e39741”，关键词=“肥胖;数字行为指导;健康行为改变;互动的建议;生活方式的改变;移动的干预;病人参与;远程医疗;电子健康; digital health; digital coach; weight loss; coaching; training; engagement; behavior changes; diabetes; type 2 diabetes; T2D", abstract="Background: Long-term weight loss in people living with obesity can reduce the risk and progression of noncommunicable diseases. Observational studies suggest that digital coaching can lead to long-term weight loss. Objective: We investigated whether an eHealth lifestyle coaching program for people living with obesity with or without type 2 diabetes led to significant, long-term (12-month) weight loss compared to usual care. Methods: In a randomized controlled trial that took place in 50 municipalities in Denmark, 340 people living with obesity with or without type 2 diabetes were enrolled from April 16, 2018, to April 1, 2019, and randomized via an automated computer algorithm to an intervention (n=200) or a control (n=140) group. Patients were recruited via their general practitioners, the Danish diabetes organization, and social media. The digital coaching intervention consisted of an initial 1-hour face-to-face motivational interview followed by digital coaching using behavioral change techniques enabled by individual live monitoring. The primary outcome was change in body weight from baseline to 12 months. Results: Data were assessed for 200 participants, including 127 from the intervention group and 73 from the control group, who completed 12 months of follow-up. After 12 months, mean body weight and BMI were significantly reduced in both groups but significantly more so in the intervention group than the control group (--4.5 kg, 95{\%} CI --5.6 to --3.4 vs --1.5 kg, 95{\%} CI --2.7 to --0.2, respectively; P<.001; and --1.5 kg/m2, 95{\%} CI --1.9 to --1.2 vs --0.5 kg/m2, 95{\%} CI --0.9 to --0.1, respectively; P<.001). Hemoglobin A1c was significantly reduced in both the intervention (--6.0 mmol/mol, 95{\%} CI --7.7 to --4.3) and control (--4.9 mmol/mol, 95{\%} CI --7.4 to --2.4) groups, without a significant group difference (all P>.46). Conclusions: Compared to usual care, digital lifestyle coaching can induce significant weight loss for people living with obesity, both with and without type 2 diabetes, after 12 months. Trial Registration: ClinicalTrials.gov NCT03788915; https://clinicaltrials.gov/ct2/show/NCT03788915 ", issn="1438-8871", doi="10.2196/39741", url="//www.mybigtv.com/2022/9/e39741", url="https://doi.org/10.2196/39741", url="http://www.ncbi.nlm.nih.gov/pubmed/36149735" }