@Article{info:doi/10.2196/30907，作者=“张慧敏和廖，玉华和韩，雪和凡，Beifang和刘，易峰和刘，Leanna M W和Lee, Yena和Subramaniapillai, Mehala和李，Lingjiang和Guo, Lan和Lu, Ciyong和McIntyre, Roger S”，标题=“基于移动应用程序的综合心理卫生保健模型筛查中国社区居民抑郁症状和事件性重度抑郁症:队列研究”，期刊=“J Med Internet Res”，年=“2022”，月=“5”，日=“20”，卷=“24”，号=“5”，页=“e30907”，关键词=“筛选;抑郁症状;事件性重度抑郁症;华人社区居民;基于电子的综合精神卫生保健模式"，摘要="背景:抑郁症在全球范围内与显著的发病率和人力资本成本相关。抑郁症状的早期筛查和及时的抑郁症病例识别和干预可以改善受影响个体的健康结果和成本效益。中国公众和学术界已经就改善抑郁症早期筛查、诊断和治疗的必要性达成共识。目的:本研究旨在利用基于移动应用程序的综合精神卫生保健模型，估计入组队列研究的中国居民阈下抑郁症状的筛查率及其相关因素，并调查阈下抑郁症状患者12个月的重度抑郁障碍(MDD)发病率及其相关因素。方法:数据来自中国抑郁症队列(DCC)研究。 A total of 4243 community residents aged 18 to 64 years living in Nanshan district, Shenzhen city, in Guangdong province, China, were encouraged to participate in the DCC study when visiting the participating primary health care centers, and 4066 (95.83{\%}) residents who met the DCC study criteria were screened for subthreshold depressive symptoms using the Patient Health Questionnaire-9 at baseline. Of the 4066 screened residents, 3168 (77.91{\%}) with subthreshold depressive symptoms were referred to hospitals to receive a psychiatric diagnosis of MDD within 12 months. Sleep duration, anxiety symptoms, well-being, insomnia symptoms, and resilience were also investigated. The diagnosis of MDD was provided by trained psychiatrists using the Mini-International Neuropsychiatric Interview. Univariate and multivariate logistic regression models were performed to explore the potential factors related to subthreshold depressive symptoms at baseline, and Cox proportional hazards models were performed to explore the potential factors related to incident MDD. Results: Anxiety symptoms (adjusted odds ratio [AOR] 1.63, 95{\%} CI 1.42-1.87) and insomnia symptoms (AOR 1.13, 95{\%} CI 1.05-1.22) were associated with an increased risk of subthreshold depressive symptoms, whereas well-being (AOR 0.93, 95{\%} CI 0.87-0.99) was negatively associated with depressive symptoms. During the follow-up period, the 12-month incidence rate of MDD among participants with subthreshold depressive symptoms was 5.97{\%} (189/3168). After incorporating all significant variables from the univariate analyses, the multivariate Cox proportional hazards model reported that a history of comorbidities (adjusted hazard ratio [AHR] 1.49, 95{\%} CI 1.04-2.14) and anxiety symptoms (AHR 1.13, 95{\%} CI 1.09-1.17) were independently associated with an increased risk of incident MDD. The 5-item World Health Organization Well-Being Index was associated with a decreased risk of incident MDD (AHR 0.90, 95{\%} CI 0.86-0.94). Conclusions: Elevated anxiety symptoms and unfavorable general well-being were significantly associated with subthreshold depressive symptoms and incident MDD among Chinese residents in Shenzhen. Early screening for subthreshold depressive symptoms and related factors may be helpful for identifying populations at high risk of incident MDD. ", issn="1438-8871", doi="10.2196/30907", url="//www.mybigtv.com/2022/5/e30907", url="https://doi.org/10.2196/30907", url="http://www.ncbi.nlm.nih.gov/pubmed/35594137" }