@文章{info:doi/10.2196/30095，作者="Mujcic, Ajla和Blankers, Matthijs和Boon, Brigitte和Berman, Anne H和Riper, Heleen和van Laar, Margriet和Engels, Rutger"，标题="癌症幸存者的数字酒精节制干预的有效性，成本-效果和成本-效用:一项实用主义随机对照试验的健康经济评价与结果》，期刊=《J medical Internet Res》，年=“2022”，月=“2”，日=“1”，卷=“24”，数=“2”，页=“e30095”，关键词=“酒精;短暂的干预;癌症幸存者;有效性;成本效益;电子健康;背景:酒精调节(AM)干预可能有助于更好的治疗结果和癌症幸存者的总体福祉。目的:本研究评估了数字AM干预MyCourse的有效性、成本效益和成本效用，并与非交互式数字癌症幸存者信息手册进行了比较。方法:采用实用的两臂平行组随机对照试验进行健康经济评估，并在随机化后3、6和12个月进行随访。 The study was conducted on the web in the Netherlands from 2016 to 2019. Participants were adult 10-year cancer survivors drinking over the Dutch-recommended drinking guidelines (≤7 standard units [10 g of alcohol] per week) with the intention to moderate or quit drinking. Overall, 103 participants were randomized and analyzed: 53 (51.5{\%}) in the MyCourse group and 50 (48.5{\%}) in the control group. In the MyCourse group, participants had access to a newly developed, digital, minimally guided AM intervention, MyCourse--Moderate Drinking. The primary outcome was the self-reported number of standard drinks (10 g of ethanol) consumed in the past 7 days at the 6-month follow-up. The secondary outcome measures were alcohol-related problems as measured by the Alcohol Use Disorders Identification Test (AUDIT) and treatment satisfaction. For the health economic evaluation, health care costs, costs because of productivity losses, and intervention costs were assessed over a 12-month horizon. Results: Alcohol use at the 6-month follow-up decreased by 38{\%} in the MyCourse group and by 33{\%} in the control group. No difference in 7-day alcohol use was found between the groups (B=2.1, 95{\%} CI −7.6 to 3.1; P=.22) at any of the follow-ups. AUDIT scores for alcohol-related problems decreased over time in both groups, showing no significant difference between the groups (Cohen d=0.3, 95{\%} CI −0.1 to 0.6; P=.21). Intervention costs per participant were estimated at US {\$}279 for the MyCourse group and US {\$}74 for the control group. The mean societal costs were US {\$}18,092 (SD 25,662) and US {\$}23,496 (SD 34,327), respectively. The MyCourse group led to fewer gained quality-adjusted life years at lower societal costs in the cost-utility analysis. In the cost-effectiveness analysis, the MyCourse group led to a larger reduction in drinking units over time at lower societal costs (incremental cost-effectiveness ratio per reduced drink: US {\$} −1158, 95{\%} CI −1609 to −781). Conclusions: At 6 months, alcohol use was reduced by approximately one-third in both groups, with no significant differences between the digital intervention MyCourse and a noninteractive web-based brochure. At 12 months, cost-effectiveness analyses showed that MyCourse led to a larger reduction in drinking units over time, at lower societal costs. The MyCourse group led to marginally fewer gained quality-adjusted life years, also at lower societal costs. Trial Registration: Netherlands Trial Register NTR6010; https://www.trialregister.nl/trial/5433 International Registered Report Identifier (IRRID): RR2-10.1186/s12885-018-4206-z ", issn="1438-8871", doi="10.2196/30095", url="//www.mybigtv.com/2022/2/e30095", url="https://doi.org/10.2196/30095", url="http://www.ncbi.nlm.nih.gov/pubmed/35103605" }