@文章{info:doi/10.2196/14617，作者=“Tsolaki, Anthoula C和Tsolaki, Magda和Pandria, Niki和Lazarou, Eftychia和Gkatzima, Olymbia和Zilidou, Vasiliki和Karagianni, Maria和Iakovidou-Kritsi, Zafiroula和Kimiskidis, Vasilios K和Bamidis, Panagiotis D”，标题=“基于载脂蛋白E基因型的基于web的轻度认知障碍干预效果:准实验研究”，期刊=《J Med Internet Res》，年=“2020”，月=“5”，日=“7”，卷=“22”，数=“5”，页=“e14617”，关键词=“轻度认知障碍;APOE \ε4美元;电脑培训;exergaming;背景:载脂蛋白E (APOE) $\epsilon$4等位基因是阿尔茨海默病和轻度认知障碍(MCI)的主要遗传危险因素。基于计算机的培训项目可以提高老年人的认知能力。然而，基于计算机的干预对MCI APOE $\epsilon$4载体的影响从未被研究过。目的:研究不同网络干预的效果和载脂蛋白e亚型特异性差异对训练结果的影响。方法:采用准实验研究设计，202名60岁及以上的MCI患者通过创新的信息和通信技术锻炼游戏平台参加了三种不同的干预方案(身体和认知[持久记忆，或LLM]，认知[主动控制，或AC]，或身体干预[体育训练控制，或PTC])。 Participants in each interventional group were subdivided into APOE $\epsilon$4 carriers and non--APOE $\epsilon$4 carriers. All participants underwent an extensive neuropsychological evaluation before and after the training, blood tests, and brain imaging. Results: All interventions resulted in multiple statistically significant cognitive benefits after the intervention. Verbal learning (California Verbal Learning Test: immediate recall test score---LLM: P=.04; AC: P<.001), working memory (digit span forward and backward test scores---AC: P=.03; PTC: P=.02 and P=.006, respectively), and long-term memory (California Verbal Learning Test: delayed recall test score---LLM: P=.02; AC: P=.002; and PTC: P=.02) were improved. There was no statistically significant difference among the intervention effects. APOE $\epsilon$4 presence moderates intervention effects as the LLM intervention improved only their task-switching processing speed (Trail Making Test, Part B: P=.03) and the PTC intervention improved only the working memory (digit span backward: P=.03). No significant performance alteration was noted for the APOE $\epsilon$4+ cognitive AC training group. Conclusions: None of the applied interventions could be identified as the optimal one; it is suggested, however, that combined cognitive and physical training and physical training via exergaming may be more effective for the high-risk MCI $\Alpha$POE $\epsilon$4+ subgroup. ", issn="1438-8871", doi="10.2196/14617", url="//www.mybigtv.com/2020/5/e14617", url="https://doi.org/10.2196/14617", url="http://www.ncbi.nlm.nih.gov/pubmed/32379048" }