@文章{信息:doi/10.2196/17734，作者=“Graham, Amanda L和Papandonatos, George D和Jacobs, Megan A和Amato, Michael S和Cha, Sarah和Cohn, Amy M和Abroms, Lorien C和Whittaker, Robyn”，标题=“优化短信以促进参与互联网戒烟治疗:来自阶乘筛选实验的结果”，期刊=“J Med Internet Res”，年=“2020”，月=“Apr”，日=“2”，量=“22”，数=“4”，页=“e17734”，关键词=“戒烟;烟草依赖;互联网;背景:吸烟仍然是可预防的死亡和疾病的主要原因。鉴于互联网戒烟干预的广泛范围和已证明的有效性，它们有可能对公众健康产生重大影响。鉴于参与和行为改变之间的剂量-反应关联，确定促进参与的战略是整个数字健康干预的优先事项。短信是一种经过验证的戒烟治疗方式，也是一种增强其他健康领域干预参与的有力战略，但尚未作为数字戒烟干预的参与战略进行测试。目的:本研究考察了4个实验性短信设计因素对成年吸烟者参与网络戒烟计划的影响。方法:我们进行了一项2{\texttimes}2{\texttimes}2{\texttimes}2全因子筛选实验，其中864名参与者在注册了免费的互联网戒烟计划并注册了其自动短信计划后，被随机分配到16个实验条件中的1个。实验因素包括个性化(开/关)，网络和文本消息平台之间的集成(开/关)，基于用户参与度的动态定制干预内容(开/关)，以及消息强度(逐渐减少vs突然下降)。 Primary outcomes were 3-month measures of engagement (ie, page views, time on site, and return visits to the website) as well as use of 6 interactive features of the internet program. All metrics were automatically tracked; there were no missing data. Results: Main effects were detected for integration and dynamic tailoring. Integration significantly increased interactive feature use by participants, whereas dynamic tailoring increased the number of features used and page views. No main effects were found for message intensity or personalization alone, although several synergistic interactions with other experimental features were observed. Synergistic effects, when all experimental factors were active, resulted in the highest rates of interactive feature use and the greatest proportion of participants at high levels of engagement. Measured in terms of standardized mean differences (SMDs), effects on interactive feature use were highest for Build Support System (SMD 0.56; 95{\%} CI 0.27 to 0.81), Choose Quit Smoking Aid (SMD 0.38; 95{\%} CI 0.10 to 0.66), and Track Smoking Triggers (SMD 0.33; 95{\%} CI 0.05 to 0.61). Among the engagement metrics, the largest effects were on overall feature utilization (SMD 0.33; 95{\%} CI 0.06 to 0.59) and time on site (SMD 0.29; 95{\%} CI 0.01 to 0.57). As no SMD >0.30 was observed for main effects on any outcome, results suggest that for some outcomes, the combined intervention was stronger than individual factors alone. Conclusions: This factorial experiment demonstrates the effectiveness of text messaging as a strategy to increase engagement with an internet smoking cessation intervention, resulting in greater overall intervention dose and greater exposure to the core components of tobacco dependence treatment that can promote abstinence. Trial Registration: ClinicalTrials.gov NCT02585206; https://clinicaltrials.gov/ct2/show/NCT02585206. International Registered Report Identifier (IRRID): RR2-10.1136/bmjopen-2015-010687 ", issn="1438-8871", doi="10.2196/17734", url="//www.mybigtv.com/2020/4/e17734", url="https://doi.org/10.2196/17734", url="http://www.ncbi.nlm.nih.gov/pubmed/32238338" }