@文章{信息:doi/10.2196/16715，作者=“郭艳红，Y Alicia和蔡，李卫平，凌华和郝，袁涛和乔，嘉颖和徐，志萌和张，韩曦和曾，刘成波，聪和李，怡然和朱，孟婷和曾，于和Penedo, Frank J”，标题=“基于微信的干预(Run4Love)对中国艾滋病毒感染者抑郁症状的影响:随机对照试验”，期刊=“J Med Internet Res”，年=“2020”，月=“2月”，日=“11”，卷=“22”，数=“2”，页数=“e16715”，关键词=“HIV;抑郁症;移动健康;微信;随机对照试验”，摘要=“背景:艾滋病毒感染者(PLWH)有较高的抑郁症状发生率。然而，针对这一弱势群体的有效心理健康干预措施寥寥无几。目的:本研究的目的是评估基于微信的干预措施Run4Love的疗效，在中国300名艾滋病毒和抑郁症(PLWHD)患者中进行随机对照试验。方法:我们从华南地区HIV门诊招募PLWH。根据流行病学研究中心抑郁量表(CES-D)对参与者进行筛查。 Those who scored 16 or higher were eligible to participate. A total of 300 eligible patients were enrolled. After obtaining informed consent from the participants, completion of a baseline survey, and collection of participants' hair samples for measuring cortisol, the participants were randomly assigned to an intervention or a control group in a 1:1 ratio. The intervention group received the Run4Love program, delivered via the popular social media app WeChat. Cognitive behavioral stress management courses and weekly reminders of exercise were delivered in a multimedia format. Participants' progress was monitored with timely and tailored feedback. The control group received usual care and a brochure on nutrition for PLWH. Data were collected at 3, 6, and 9 months. The primary outcome was depression, which was measured by a validated instrument. Results: Participants in the intervention and control groups were comparable at baseline; about 91.3{\%} (139/150), 88.3{\%} (132/150), and 86.7{\%} (130/150) participants completed the 3-, 6-, and 9-month follow-ups, respectively. At the 3-month follow-up, a significant reduction in CES-D score was observed in the intervention group (from 23.9 to 17.7 vs from 24.3 to 23.8; mean difference=−5.77, 95{\%} CI −7.82 to −3.71; P<.001; standard effect size d=0.66). The mean changes in CES-D score from baseline to the 6- and 9-month follow-ups between the two groups remained statistically significant. No adverse events were reported. Conclusions: The WeChat-based mobile health (mHealth) intervention Run4Love significantly reduced depressive symptoms among PLWHD, and the effect was sustained. An app-based mHealth intervention could provide a feasible therapeutic option for many PLWHD in resource-limited settings. Further research is needed to assess generalizability and cost-effectiveness of this intervention. Trial Registration: Chinese Clinical Trial Registry ChiCTR-IPR-17012606; http://www.chictr.org.cn/showproj.aspx?proj=21019 (Archived by WebCite at https://www.webcitation.org/78Bw2vouF) ", issn="1438-8871", doi="10.2196/16715", url="//www.mybigtv.com/2020/2/e16715", url="https://doi.org/10.2196/16715" }