@文章{信息:doi/10.2196/14754，作者=“Schure, Mark B和Lindow, Janet C和Greist, John H和Nakonezny, Paul A和Bailey, Sandra J和Bryan, William L和Byerly, Matthew J”，标题=“在有抑郁症状的成年人社区人群中使用全自动基于互联网的认知行为治疗干预:随机对照试验”，期刊=“J Med Internet Res”，年=“2019”，月=“11月”，日=“18”，卷=“21”，数=“11”，页=“e14754”，关键词=“基于网络的认知行为疗法;直肠;抑郁症状;农村人口;个随机对照试验;随机对照试验;背景:尽管基于互联网的认知行为疗法(iCBT)干预可以减轻抑郁症状，但其有效性存在很大差异。目的:本研究的目的是评估名为Thrive的iCBT干预的有效性，该干预的目的是在对有抑郁症状的农村社区成年人进行全自动独立干预时提高参与度。方法:在不排除诊断或治疗的情况下，通过开放网站从社区招募了343名有抑郁症状的成年人，并将其随机1:1分为Thrive干预组或对照组。 Using self-reports, participants were evaluated at baseline and 4 and 8 weeks for the primary outcome of depression symptom severity and secondary outcome measures of anxiety symptoms, work and social adjustment, psychological resilience, and suicidal ideation. Results: Over the 8-week follow-up period, the intervention group (n=181) had significantly lower depression symptom severity than the control group (n=162; P<.001), with a moderate treatment effect size (d=0.63). Moderate to near-moderate effect sizes favoring the intervention group were observed for anxiety symptoms (P<.001; d=0.47), work/social functioning (P<.001; d=0.39), and resilience (P<.001; d=0.55). Although not significant, the intervention group was 45{\%} less likely than the control group to experience increased suicidal ideation (odds ratio 0.55). Conclusions: These findings suggest that the Thrive intervention was effective in reducing depression and anxiety symptom severity and improving functioning and resilience among a mostly rural community population of US adults. The effect sizes associated with Thrive were generally larger than those of other iCBT interventions delivered as a fully automated, stand-alone intervention. Trial Registration: ClinicalTrials.gov NCT03244878; https://clinicaltrials.gov/ct2/show/NCT03244878 ", issn="1438-8871", doi="10.2196/14754", url="//www.mybigtv.com/2019/11/e14754/", url="https://doi.org/10.2196/14754", url="http://www.ncbi.nlm.nih.gov/pubmed/31738173" }