@文章{信息:doi/10.2196/14729，作者=“李怡然和郭，燕和洪，Y Alicia和朱，孟婷和曾，程波和乔，嘉颖和徐，志萌和张，韩曦和曾，于和蔡，李卫平，凌华和刘丛，基于微信的艾滋病和抑郁症患者自杀干预的机制和效果:，期刊=《J Med Internet Res》，年=“2019”，月=“11”，日=“27”，卷=“21”，数=“11”，页数=“e14729”，关键词=“HIV;移动健康;抑郁症;背景:艾滋病毒携带者和抑郁症患者的自杀率很高。移动健康(mHealth)干预措施的研究表明，在改善艾滋病毒携带者和抑郁症患者的心理健康方面具有可行性、可接受性和有效性。然而，很少有研究考察移动健康干预自杀的机制和效果。目的:本研究旨在研究基于微信的干预(Run4Love)对中国艾滋病毒携带者和抑郁症患者自杀的机制和影响，同时考虑感知压力和抑郁症状作为中介。方法:从一家大型艾滋病毒或艾滋病治疗医院的门诊招募了300名艾滋病毒和抑郁症患者，随机分为Run4Love组和对照组。在基线、3个月、6个月和9个月的随访中收集数据。 Path analysis modeling, with longitudinal data, was used in data analyses. Results: The Run4Love mHealth intervention had a direct effect on reducing suicide rate at the 6-month follow-up (beta=−.18, P=.02) and indirect effect through reducing perceived stress and depressive symptoms at the 3-month follow-up (beta=−.09, P=.001). A partial mediating effect between perceived stress and depressive symptoms accounted for 33{\%} (--0.09/--0.27) of the total effect. Conclusions: Through path analyses, we understood the mechanisms and effects of an mHealth intervention on suicide prevention. The findings underscored the importance of stress reduction and depression treatment in such a program. We call for more effective suicide prevention, especially mHealth interventions targeting the vulnerable population of people living with HIV and depression. Trial Registration: Chinese Clinical Trial Registry ChiCTR-IPR-17012606; http://www.chictr.org.cn/showprojen.aspx?proj=21019 ", issn="1438-8871", doi="10.2196/14729", url="//www.mybigtv.com/2019/11/e14729", url="https://doi.org/10.2196/14729", url="http://www.ncbi.nlm.nih.gov/pubmed/31774411" }