@Article{信息:doi 10.2196 / / jmir。5806，作者=“Saslow, Laura R和Mason, Ashley E和Kim, Sarah和Goldman, Veronica和Ploutz-Snyder, Robert和Bayandorian, Hovig和Daubenmier, Jennifer和Hecht, Frederick M和Moskowitz, Judith T”，标题=“在超重的2型糖尿病患者中比较极低碳水化合物生酮饮食和生活方式建议与盘子法饮食的在线干预:一项随机对照试验”，期刊=“J Med Internet Res”，年=“2017”，月=“2”，日=“13”，卷=“19”，数=“2”，页=“e36”，关键词=“eHealth;饮食;减肥;背景:2型糖尿病是一种常见的慢性疾病，饮食是治疗的一个重要方面。在我们之前的试验中，我们发现，建议遵循极低碳水化合物生酮饮食和改变生活方式因素(体育活动、睡眠、积极的影响、专注力)有助于超重的2型糖尿病或前驱糖尿病患者改善血糖控制和减肥。这是一次面对面的干预，对于没有时间、灵活性、交通工具、社会支持和/或经济资源的人来说，这可能是一个障碍。目的:目的是确定基于我们之前的建议(自由选择极低碳水化合物生酮饮食与生活方式因素;“干预”)或基于美国糖尿病协会“创造你的餐盘”(“控制”)的在线饮食计划，将改善2型糖尿病超重患者的血糖控制和其他健康结果。 Methods: In this pilot feasibility study, we randomized overweight adults (body mass index ≥25) with type 2 diabetes (glycated hemoglobin [HbA1c] 6.5{\%}-9.0{\%}) to a 32-week online intervention based on our previous recommendations (n=12) or an online diet program based around a plate method diet (n=13) to assess the impact of each intervention on glycemic control and other health outcomes. Primary and secondary outcomes were analyzed by mixed-effects linear regression to compare outcomes by group. Results: At 32 weeks, participants in the intervention group reduced their HbA1c levels more (estimated marginal mean [EMM] --0.8{\%}, 95{\%} CI --1.1{\%} to --0.6{\%}) than participants in the control group (EMM --0.3{\%}, 95{\%} CI --0.6{\%} to 0.0{\%}; P=.002). More than half of the participants in the intervention group (6/11, 55{\%}) lowered their HbA1c to less than 6.5{\%} versus 0{\%} (0/8) in the control group (P=.02). Participants in the intervention group lost more weight (EMM --12.7 kg, 95{\%} CI --16.1 to --9.2 kg) than participants in the control group (EMM --3.0 kg, 95{\%} CI --7.3 to 1.3 kg; P<.001). A greater percentage of participants lost at least 5{\%} of their body weight in the intervention (10/11, 90{\%}) versus the control group (2/8, 29{\%}; P=.01). Participants in the intervention group lowered their triglyceride levels (EMM --60.1 mg/dL, 95{\%} CI --91.3 to --28.9 mg/dL) more than participants in the control group (EMM --6.2 mg/dL, 95{\%} CI --46.0 to 33.6 mg/dL; P=.01). Dropout was 8{\%} (1/12) and 46{\%} (6/13) for the intervention and control groups, respectively (P=.07). Conclusions: Individuals with type 2 diabetes improved their glycemic control and lost more weight after being randomized to a very low-carbohydrate ketogenic diet and lifestyle online program rather than a conventional, low-fat diabetes diet online program. Thus, the online delivery of these very low-carbohydrate ketogenic diet and lifestyle recommendations may allow them to have a wider reach in the successful self-management of type 2 diabetes. Trial Registration: ClinicalTrials.gov NCT01967992; https://clinicaltrials.gov/ct2/show/NCT01967992 (Archived by WebCite at http://www.webcitation.org/6o0fI9Mkq) ", issn="1438-8871", doi="10.2196/jmir.5806", url="//www.mybigtv.com/2017/2/e36/", url="https://doi.org/10.2196/jmir.5806", url="http://www.ncbi.nlm.nih.gov/pubmed/28193599" }