@Article{信息:doi 10.2196 / / jmir。8241，作者=“Perry, Yael和werna - seidler, Aliza和Calear, Alison和Mackinnon, Andrew和King, Catherine和Scott, Jan和Merry, Sally和Fleming, Theresa和Stasiak, Karolina和Christensen, Helen和Batterham, Philip J”，标题=“预防最后一年级中学生的抑郁:校本随机对照试验”，期刊=“J医学互联网研究”，年=“2017”，月=“11”，日=“02”，卷=“19”，数=“11”，页=“e369”，关键词=“预防;抑郁症;青少年;背景:抑郁症通常在青春期第一次出现。越来越多的证据表明，如果在学校环境中实施，普遍的抑郁症预防项目可能有能力减少抑郁症的影响。目的:本试验调查了SPARX-R的有效性。SPARX-R是一种游戏化的在线认知行为治疗干预，用于预防抑郁症，相对于在面对重要压力源——中学期末考试之前向学生提供的注意匹配控制干预。假设在压力源之前提供预防干预会减少相对于对照组的抑郁症状。方法:在澳大利亚悉尼的10所公立学校进行了一项聚类随机对照试验。参与者为540名大四中学生(平均16.7岁[SD 0.51]岁)，在学校层面随机分配到SPARX-R或对照干预组。 Interventions were delivered weekly in 7 modules, each taking approximately 20 to 30 minutes to complete. The primary outcome was symptoms of depression as measured by the Major Depression Inventory. Intention-to-treat analyses were performed. Results: Compared to controls, participants in the SPARX-R condition (n=242) showed significantly reduced depression symptoms relative to the control (n=298) at post-intervention (Cohen d=0.29) and 6 months post-baseline (d=0.21) but not at 18 months post-baseline (d=0.33). Conclusions: This is the first trial to demonstrate a preventive effect on depressive symptoms prior to a significant and universal stressor in adolescents. It demonstrates that an online intervention delivered in advance of a stressful experience can reduce the impact of such an event on the potential development or exacerbation of depression. Trial Registration: Australian New Zealand Clinical Trials Registry ACTRN12614000316606; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=365986 (Archived by WebCite at http://www.webcitation.org/ 6u7ou1aI9) ", issn="1438-8871", doi="10.2196/jmir.8241", url="//www.mybigtv.com/2017/11/e369/", url="https://doi.org/10.2196/jmir.8241", url="http://www.ncbi.nlm.nih.gov/pubmed/29097357" }