@Article{信息:doi 10.2196 / / jmir。2015，作者=“Dowshen, Nadia和Kuhns, Lisa M和Johnson, Amy和Holoyda, Brian James和Garofalo, Robert”，标题=“提高抗逆转录病毒治疗对青少年艾滋病毒/艾滋病患者的依从性:使用个性化，交互式，每日短信提醒的初步研究”，期刊=“J医学互联网研究”，年=“2012”，月=“Apr”，日=“05”，卷=“14”，数=“2”，页=“e51”，关键词=“青少年;艾滋病毒/艾滋病;依从性;短信;短消息服务;短信;背景:对于患有人类免疫缺陷病毒(HIV)/获得性免疫缺陷综合征(AIDS)的青年，不坚持抗逆转录病毒治疗(ART)可能导致不良的健康结果和显著降低预期寿命。目的:评价短信服务(SMS)或短信提醒提高青少年艾滋病毒/艾滋病抗逆转录病毒治疗依从性的可行性、可接受性和初步疗效。方法:我们从2009年到2010年在一个为感染艾滋病毒/艾滋病的青年提供临床服务的社区卫生中心采用前后设计进行了这项前瞻性试点研究。 Eligibility criteria included HIV-positive serostatus, age 14--29 years, use of a personal cell phone, English-speaking, and being on ART with documented poor adherence. During the 24-week study period, participants received personalized daily SMS reminders and a follow-up message 1 hour later assessing whether they took the medication, and asking participants to respond via text message with the number 1 if they took the medication and 2 if they did not. Outcome measures were feasibility, acceptability, and adherence. Self-reported adherence was determined using the visual analog scale (VAS) and AIDS Clinical Trial Group (ACTG) questionnaire 4-day recall. Viral load and CD4 cell count were followed as biomarkers of adherence and disease progression at 0, 12, and 24 weeks. Results: Participants (N = 25) were mean age 23 (range 14--29) years, 92{\%} (n = 23) male, 60{\%} (n = 15) black, and 84{\%} (n = 21) infected through unprotected sex. Mean VAS scores significantly increased at 12 and 24 weeks in comparison with baseline (week 0: 74.7, week 12: 93.3, P < .001; week 24: 93.1, P < .001). ACTG questionnaire 4-day recall also improved (week 0: 2.33, week 12: 3.24, P = .002; week 24: 3.19, P = .005). There was no significant difference in CD4 cell count or viral load between baseline and 12- or 24-week follow-up, although there was a trend toward improvement of these biomarkers and a small to moderate standardized effect size (range of Cohen d: --0.51 to 0.22). Of 25 participants, 21 (84{\%}) were retained, and 20 of the 21 (95{\%}) participants who completed the study found the intervention helpful to avoid missing doses. Conclusions: In this pilot study, personalized, interactive, daily SMS reminders were feasible and acceptable, and they significantly improved self-reported adherence. Larger controlled studies are needed to determine the impact of this intervention on ART adherence and other related health outcomes for youth living with HIV/AIDS. ", issn="1438-8871", doi="10.2196/jmir.2015", url="//www.mybigtv.com/2012/2/e51/", url="https://doi.org/10.2196/jmir.2015", url="http://www.ncbi.nlm.nih.gov/pubmed/22481246" }