横断研究JO - JMIR公共卫生监测SP - e32968 VL - 8 IS - 8kw -神经认知表现KW - HIV血清状态KW -抑郁症状KW -体力活动水平KW -中介作用KW - HIV KW -抑郁KW -体力活动KW -神经认知KW -心理健康KW -公共卫生AB -背景:神经认知障碍在中国老年人中普遍存在。在感染艾滋病毒的老年人中问题更大。目的:本研究旨在比较老年HIV感染者和HIV阴性对照组之间的神经认知表现，并探讨HIV状态和神经认知表现之间的关系是否由抑郁症状和身体活动水平介导。方法:在中国永州进行横断面研究。所有登记在册的年龄≥50岁的艾滋病毒感染者都被邀请参加。根据年龄、性别和感染艾滋病毒的老年人的正规教育年数分布，使用频率匹配从一般人群中抽取HIV阴性对照样本。共有315名老年艾滋病毒感染者和350名艾滋病毒阴性对照组完成了面对面访谈和七个领域的综合神经心理学评估(学习、记忆、工作记忆、语言流畅性、处理速度、执行功能和运动技能)。结果:与HIV阴性对照相比，携带HIV的老年人在全球得分和所有七个领域表现更差(P<.05)。HIV感染与较高的抑郁症状(P<.001)和较低的体力活动水平(P<.001)相关。 Depressive symptoms and physical activity were negatively correlated (P<.001). Depressive symptoms and level of physical activity mediated the association between HIV status and global z-score and four domain z-scores of neurocognitive performance (learning, memory, verbal fluency, and processing speed). Conclusions: Change in mental health and physical activity after HIV infection may partially explain why older people living with HIV are more susceptible to neurocognitive impairment. Promoting mental health and physical activity are potential entry points to slow down the progress of neurocognitive impairment among older people living with HIV. SN - 2369-2960 UR - https://publichealth.www.mybigtv.com/2022/8/e32968 UR - https://doi.org/10.2196/32968 UR - http://www.ncbi.nlm.nih.gov/pubmed/35984684 DO - 10.2196/32968 ID - info:doi/10.2196/32968 ER -