TY - JOUR AU - Suzuki, Yukio AU - Sukegawa, Akiko AU - Ueda, Yutaka AU - Sekine, Masayuki AU - Enomoto, Takayuki AU - Melamed, Alexander AU - Wright, Jason D AU - Miyagi, Etsuko PY - 2022 DA - 2022/5/25 TI -基于网络的宫颈癌幸存者故事对父母行为和考虑为女儿接种人类乳头瘤病毒疫苗的意愿的影响:随机对照试验乔- JMIR公共卫生Surveill SP - e34715六世- 8 - 5 KW -人类乳头状瘤病毒疫苗接种KW -疫苗接种KW -疫苗KW -疫苗犹豫KW -癌症幸存者KW -叙述故事KW -基于web的KW -随机对照试验KW -个随机对照试验KW - HPV KW -人类乳头状瘤病毒KW -病毒KW -犹豫KW -癌症KW -意愿KW -行为KW -父AB -背景:在日本，政府建议已经暂停，向有资格接种人乳头瘤病毒(HPV)疫苗的子女的父母提供充分的信息对于克服疫苗犹豫至关重要。然而，先前评估简单教育工具效果的试验显示，在增加父母为女儿接种疫苗的意愿方面，效果有限。目的:本试验的目的是评估宫颈癌幸存者的故事对父母为女儿接种HPV疫苗的意愿的影响。方法:在这项在线实施的双盲随机对照试验(RCT)中，我们于2020年3月通过网页招募了2175名30-59岁的参与者，并向他们提供了一份与以下方面有关的问卷:对HPV感染和HPV疫苗接种的认识，以及HPV疫苗接种的意愿。参与者被随机分配(1:1)看一个关于宫颈癌幸存者或什么都没有的短片，按性别(男性vs女性)和在随机分组之前是否愿意接种HPV疫苗(是vs否)进行分层。主要终点是同意为女儿接种HPV疫苗的父母的比例。次要终点是同意为女儿接种HPV疫苗的父母的比例和3个月时的HPV疫苗接种率。采用风险比(RR)评价干预效果。 Results: Of 2175 participants, 1266 (58.2%) were men and 909 (41.8%) were women. A total of 191 (8.8%) participants were willing to consider HPV vaccination prior to randomization. Only 339 (15.6%) participants were aware of the benefits of HPV vaccination. In contrast, 562 (25.8%) participants were aware of the adverse events of HPV vaccination. Although only 476 (21.9%) of the respondents displayed a willingness to vaccinate their daughters for HPV, there were 7.5% more respondents in the intervention group with this willingness immediately after watching the short film (RR 1.41, 95% CI 1.20-1.66). In a subanalysis, the willingness in males to vaccinate daughters was significantly higher in the intervention group (RR 1.50, 95% CI 1.25-1.81); however, such a difference was not observed among females (RR 1.21, 95% CI 0.88-1.66). In the follow-up survey at 3 months, 1807 (83.1%) participants responded. Of these, 149 (8.2%) responded that they had had their daughters receive vaccination during the 3 months, even though we could not see the effect of the intervention: 77 (7.9%) in the intervention group and 72 (8.7%) in the control group. Conclusions: A cervical cancer survivor’s story increases immediate willingness to consider HPV vaccination, but the effect does not last for 3 months. Furthermore, this narrative approach to parents does not increase vaccination rates in children eligible for HPV vaccination. Trial Registration: UMIN Clinical Trials Registry UMIN000039273; https://tinyurl.com/bdzjp4yf SN - 2369-2960 UR - https://publichealth.www.mybigtv.com/2022/5/e34715 UR - https://doi.org/10.2196/34715 UR - http://www.ncbi.nlm.nih.gov/pubmed/35421848 DO - 10.2196/34715 ID - info:doi/10.2196/34715 ER -