TY -的盟Workneh Meklit AU -哈米尔,马修·M AU - Kakooza弗朗西斯AU -曼丁哥人,伊曼纽尔AU -瓦格纳,杰西卡盟——Mbabazi橄榄盟——Mugasha罗德尼盟——Kajumbula亨利AU - Walwema,理查德•AU - Zenilman乔纳森•AU - Musinguzi帕特里克盟——Kyambadde彼得AU - Lamorde,默罕默德盟——Manabe Yukari C PY - 2020 DA - 2020/6/10 TI -抗菌素耐药性淋病奈瑟氏菌的新监测项目在乌干达实施:监测报告JO - JMIR公共卫生监测SP - e17009 VL - 6is - 2kw -淋病KW -抗菌素耐药性KW -监测KW -乌干达KW -性病KW - STI KW -性传播KW -淋病奈瑟菌KW -抗生素耐药性，EGASP AB -背景:在东南亚，淋病奈瑟菌(俗称淋病)对所有一线治疗都产生了耐药性。东非历来没有或基本没有淋病监测项目，虽然人们认识到存在耐药淋病，但其耐药程度在很大程度上是未知的。2016年，世界卫生组织在乌干达启动了淋球菌抗微生物药物强化监测计划(EGASP)，以监测耐药性趋势。目的:本研究对乌干达坎帕拉男性尿道分泌物综合征的大型监测项目中的淋病和抗生素耐药性进行特征分析。方法:男性尿道炎就诊哨点诊所提供人口统计学信息、行为数据和符合世界卫生组织EGASP协议的尿道拭子，用于培养、鉴定和抗生素敏感性测试，使用2种方法-纸片扩散(Kirby-Bauer试验)和Etest (BioMérieux Inc)。一部分样本进行了详细的抗菌素耐药性测试。结果:2016年9月至2018年2月收集的639份样本中，400份(62.6%)培养阳性，414份(64.8%)有淋病的显微证据。收集样本的男性的平均年龄为26.9岁(SD为9.6岁)，7.2%(46/639)报告患有艾滋病毒。柯比-鲍尔圆盘扩散法显示对环丙沙星、四环素和青霉素的高水平耐药(大于90%)，检测结果显示2.1%(4/188)的阿奇霉素敏感性降低。 Of the early isolates that underwent detailed characterization, 60.3% (70/116) were culture-positive, 94% (66/69) isolates were either ciprofloxacin-resistant or ciprofloxacin-intermediate by Etest, 96% (65/68) were azithromycin-sensitive, and 96% (66/69) were gentamicin-sensitive. Resistance profiles were comparable between methods except for ceftriaxone (disk diffusion: 68/69, 99%; Etest: 67/69, 97%) and for gentamicin (disk diffusion: 2/8, 25%; Etest: 66/69, 96%) sensitivity. Conclusions: This is the first report from a systematic gonorrhea surveillance program in Uganda. Findings demonstrated resistance or increased minimum inhibitory concentration to all key antigonococcal antibiotics. There was evidence of poor antibiotic stewardship, near-universal resistance to several antibiotics, and emerging resistance to others. Individuals in the population sampled were at exceptionally high risk of STI and HIV infection requiring intervention. Ongoing surveillance efforts to develop interventions to curtail antimicrobial-resistant gonorrhea are needed. SN - 2369-2960 UR - http://publichealth.www.mybigtv.com/2020/2/e17009/ UR - https://doi.org/10.2196/17009 UR - http://www.ncbi.nlm.nih.gov/pubmed/32519969 DO - 10.2196/17009 ID - info:doi/10.2196/17009 ER -