%0期刊文章%@ 2369- 2960% I JMIR出版物%V 8%卡塔尔世界杯8强波胆分析 N 5% P e29343%美国与COVID-19死亡相关的因素:队列研究%A Chen, an- i %A Xu,Hua %A Krause,Trudy Millard %A Greenberg,Raymond %A Dong,Xiao %A Jiang,Xiaoqian %+德州大学休斯顿健康科学中心生物医学信息学学院，7000 Fannin St.， Texas, 77030, United States, 1 713 500 3930, xiaoqian.jiang@uth.tmc.edu %K COVID-19 %K危险因素%K生存分析%K队列研究%K EHR数据%D 2022 %7 12.5.2022 %9原始论文%J JMIR公共卫生监测%G英文%X背景:自2020年2月在美国发现首批COVID-19病例以来，美国的发病率一直很高。了解导致严重后果的风险因素可以确定最脆弱的人群，并有助于决策。目的:本研究旨在从大型国家个人级数据集中评估与covid -19相关死亡相关的因素。方法:采用Optum去识别COVID-19电子健康记录(EHR)数据集进行队列研究;从2020年2月1日到2020年8月31日，研究人员观察了1,271,033名成年参与者，直到他们因COVID-19死亡、因其他原因死亡或研究结束。构建Cox比例风险模型以评估每种患者特征的风险。结果:共有1,271,033名参与者(年龄:平均52.6岁，SD 17.9岁;男性:507,574/1,271,033,39.93%)被纳入研究，3315例(0.26%)死亡归因于COVID-19。 Factors associated with COVID-19–related death included older age (≥80 vs 50-59 years old: hazard ratio [HR] 13.28, 95% CI 11.46-15.39), male sex (HR 1.68, 95% CI 1.57-1.80), obesity (BMI ≥40 vs <30 kg/m2: HR 1.71, 95% CI 1.50-1.96), race (Hispanic White, African American, Asian vs non-Hispanic White: HR 2.46, 95% CI 2.01-3.02; HR 2.27, 95% CI 2.06-2.50; HR 2.06, 95% CI 1.65-2.57), region (South, Northeast, Midwest vs West: HR 1.62, 95% CI 1.33-1.98; HR 2.50, 95% CI 2.06-3.03; HR 1.35, 95% CI 1.11-1.64), chronic respiratory disease (HR 1.21, 95% CI 1.12-1.32), cardiac disease (HR 1.10, 95% CI 1.01-1.19), diabetes (HR 1.92, 95% CI 1.75-2.10), recent diagnosis of lung cancer (HR 1.70, 95% CI 1.14-2.55), severely reduced kidney function (HR 1.92, 95% CI 1.69-2.19), stroke or dementia (HR 1.25, 95% CI 1.15-1.36), other neurological diseases (HR 1.77, 95% CI 1.59-1.98), organ transplant (HR 1.35, 95% CI 1.09-1.67), and other immunosuppressive conditions (HR 1.21, 95% CI 1.01-1.46). Conclusions: This is one of the largest national cohort studies in the United States; we identified several patient characteristics associated with COVID-19–related deaths, and the results can serve as the basis for policy making. The study also offered directions for future studies, including the effect of other socioeconomic factors on the increased risk for minority groups. %M 35377319 %R 10.2196/29343 %U https://publichealth.www.mybigtv.com/2022/5/e29343 %U https://doi.org/10.2196/29343 %U http://www.ncbi.nlm.nih.gov/pubmed/35377319