%0杂志文章%@ 2369-2960 %I JMIR出版物%V 8% 卡塔尔世界杯8强波胆分析N 3% P e25803% T佐剂三价免疫第一季流感疫苗接种后的相关不良事件:回顾性队列研究%A de Lusignan,Simon %A Tsang,Ruby S M %A Akinyemi,Oluwafunmi %A Lopez Bernal,Jamie %A Amirthalingam,Gayatri %A Sherlock,Julian %A Smith,Gillian %A Zambon,Maria %A Howsam,Gary %A Joy,Mark %+牛津大学，Eagle House 7, Walton Well road, OX2 6ED，英国，44 7713632524，simon.delusignan@phc.ox.ac.uk %K流感%K流感疫苗%K感兴趣的不良事件%K计算机化医疗记录系统%K哨点监测%D 2022 %7 28.3.2022 %9原始论文%J JMIR公共卫生监测%G英文%X背景:接种疫苗是预防季节性流感最有效的形式;英国有一个覆盖目标人群的国家流感疫苗接种计划。已知流感疫苗与一些常见的轻微不良事件(AEIs)相关，但尚不清楚在2018/2019流感季节首次提供的佐剂三价流感疫苗(aTIV)是否比其他类型的疫苗与更多的AEIs相关。目的:我们旨在比较2018/2019季节提供的不同类型季节性流感疫苗相关AEIs的发生率。方法:我们使用来自皇家全科医师学院研究和监测中心哨点网络数据库的计算机化医疗记录数据进行了一项回顾性队列研究。我们提取了2018/2019年流感季节欧洲药品管理局指定的aei的疫苗暴露和咨询数据。我们采用了自我控制的病例系列设计;疫苗接种后AEIs的计算相对发病率(RI); and compared the incidence of AEIs associated with aTIV, the quadrivalent influenza vaccine, and the live attenuated influenza vaccine. We also compared the incidence of AEIs for vaccinations that took place in a practice with those that took place elsewhere. Results: A total of 1,024,160 individuals received a seasonal influenza vaccine, of which 165,723 individuals reported a total of 283,355 compatible symptoms in the 2018/2019 season. Most AEIs occurred within 7 days following vaccination, with a seasonal effect observed. Using aTIV as the reference group, the quadrivalent influenza vaccine was associated with a higher incidence of AEIs (RI 1.46, 95% CI 1.41-1.52), whereas the live attenuated influenza vaccine was associated with a lower incidence of AEIs (RI 0.79, 95% CI 0.73-0.83). No effect of vaccination setting on the incidence of AEIs was observed. Conclusions: Routine sentinel network data offer an opportunity to make comparisons between safety profiles of different vaccines. Evidence that supports the safety of newer types of vaccines may be reassuring for patients and could help improve uptake in the future. %M 35343907 %R 10.2196/25803 %U https://publichealth.www.mybigtv.com/2022/3/e25803 %U https://doi.org/10.2196/25803 %U http://www.ncbi.nlm.nih.gov/pubmed/35343907