%0期刊文章%@ 2369-2960 %I JMIR出版物%V 7% 卡塔尔世界杯8强波胆分析N 12% P e29187% T网络讨论和澳大利亚Tapentadol和Oxycodone的非法街头销售:流行病学监测研究%A Black,Joshua %A Margolin,Zachary R %A Bau,Gabrielle %A Olson,Richard %A Iwanicki,Janetta L %A Dart,Richard C %+洛基山毒药和药物安全，1391 N Speer Blvd， #600, M/C 0180，丹佛，CO, 80204，美国，1 303 389 1652,joshua.black@rmpds.org %K澳大利亚%K阿片类药物%K网络讨论%K导流%D 2021 %7 20.12.2021 %9原始论文%J JMIR公共卫生监测%G英文%X背景:阿片类药物使用障碍及其后果是澳大利亚人长期关注的公共卫生问题。网络活动已被用于了解在澳大利亚以外的环境中对药物安全性和药物转移的看法。互联网的匿名性为监视和询问特定的隐蔽行为提供了几个优势，例如转移或讨论传统监视方法可能受到限制的敏感主题。目的:本研究旨在描述网络帖子的内容，并比较来自澳大利亚来源的非法销售tapentadol和oxycodone的报告。首先，对帖子内容进行评估，以确定网络讨论是否鼓励或不鼓励药物的正确治疗使用。其次，我们假设tapentadol的街头价格和非法销售比羟考酮更少。方法:使用研究的滥用、转移和成瘾相关监视系统网络监控程序收集2017年至2019年期间起源于澳大利亚的网络帖子。使用手动编码过程，来自社交媒体、博客和论坛的非结构化帖子内容被分类为与可能导致伤害的危害和行为相关的讨论主题。 Illicit sales data in a structured format were collected through a crowdsourcing website between 2016 and 2019 using the Researched Abuse, Diversion, and Addiction-Related Surveillance System StreetRx Program. In total, 2 multivariable regression models assessed the differences in illicit price and number of sales. Results: A total of 4.7% (28/600) of tapentadol posts discussed an adverse event, whereas 10.27% (95% CI 9.32-11.21) of oxycodone posts discussed this topic. A total of 10% (60/600) of tapentadol posts discussed unsafe use or side effects, whereas 20.17% (95% CI 18.92-21.41) of oxycodone posts discussed unsafe use or side effects. There were 31 illicit sales reports for tapentadol (geometric mean price per milligram: Aus $0.12 [US $0.09]) and 756 illicit sales reports for oxycodone (Aus $1.28 [US $0.91]). Models detected no differences in the street price or number of sales between the drugs when covariates were included, although the potency of the pill significantly predicted the street price (P<.001) and availability predicted the number of sales (P=.03). Conclusions: Australians searching the web for opinions could judge tapentadol as safer than oxycodone because of the web post content. The illicit sales market for tapentadol was smaller than that of oxycodone, and drug potency and licit availability are likely important factors influencing the illicit market. %M 34932012 %R 10.2196/29187 %U https://publichealth.www.mybigtv.com/2021/12/e29187 %U https://doi.org/10.2196/29187 %U http://www.ncbi.nlm.nih.gov/pubmed/34932012