%0杂志文章%@ 2369- 2960% I JMIR出版物%V 7%卡塔尔世界杯8强波胆分析 N 11% P e25976% T晚期上皮性卵巢癌组织学亚型的长期生存率:基于人群监测、流行病学和最终结果数据库的研究+厦门大学第一附属医院妇产科，361003，厦门镇海路55号，86 5922139531，zhoujuan@xmu.edu.cn %K卵巢上皮癌%K幸存者%K组织学%K存活率%K存活%K卵巢癌%K监测%K流行病学%K妇女健康%K生殖健康%K监测，流行病学和最终结果%K卵巢%K肿瘤%K存活%K长期结果%K上皮%D 2021 %7 17.11.2021 %9原始论文%J JMIR公共卫生监测%G英文%X背景:晚期上皮性卵巢癌(EOC)的实际长期生存率很少有报道。目的:本研究旨在评估组织学亚型在预测晚期EOC长期幸存者(≥5年)预后中的作用。方法:我们使用美国监测、流行病学和最终结果癌症数据，对2000年至2014年诊断为III-IV期EOC患者的数据进行回顾性分析。我们使用卡方检验、Kaplan-Meier分析和多变量Cox比例风险模型进行分析。结果:本研究共纳入8050例患者，其中浆液性、子宫内膜样、透明细胞和粘液性肿瘤患者分别为6929例(86.1%)、743例(9.2%)、237例(2.9%)和141例(1.8%)。在91个月的中位随访中，最常见的死亡原因是原发性卵巢癌(80.3%)，其次是其他癌症(8.1%)、其他死亡原因(7.3%)、心脏相关死亡(3.2%)和非恶性肺部疾病(3.2%)。浆液亚型的患者更有可能死于原发性卵巢癌，粘液亚型的患者更有可能死于其他癌症和心脏相关疾病。 Multivariate Cox analysis showed that patients with endometrioid (hazard ratio [HR] 0.534, P<.001), mucinous (HR 0.454, P<.001), and clear cell (HR 0.563, P<.001) subtypes showed better ovarian cancer-specific survival than those with the serous subtype. Similar results were found regarding overall survival. However, ovarian cancer–specific survival and overall survival were comparable among those with endometrioid, clear cell, and mucinous tumors. Conclusions: Ovarian cancer remains the primary cause of death in long-term ovarian cancer survivors. Moreover, the probability of death was significantly different among those with different histological subtypes. It is important for clinicians to individualize the surveillance program for long-term ovarian cancer survivors. %M 34787583 %R 10.2196/25976 %U https://publichealth.www.mybigtv.com/2021/11/e25976 %U https://doi.org/10.2196/25976 %U http://www.ncbi.nlm.nih.gov/pubmed/34787583