@文章{信息:doi/10.2196/34715，作者="Suzuki, Yukio和Sukegawa, Akiko和Ueda, Yutaka和Sekine, Masayuki和Enomoto, Takayuki和Melamed, Alexander和Wright, Jason D和Miyagi, Etsuko"，标题="网络宫颈癌幸存者的故事对父母的行为和意愿的影响，考虑为女儿接种人类乳头瘤病毒疫苗:随机控制试验”，期刊=“JMIR公共卫生监测”，年=“2022”，月=“5”，日=“25”，卷=“8”，数=“5”，页=“e34715”，关键词=“人乳头瘤病毒疫苗接种;疫苗接种;疫苗;疫苗犹豫;癌症幸存者;叙述故事;基于web的;随机对照试验;个随机对照试验; HPV; human papilloma virus; virus; hesitancy; cancer; willingness; behavior; parent", abstract="Background: Providing adequate information to parents who have children eligible for human papillomavirus (HPV) vaccination is essential to overcoming vaccine hesitancy in Japan, where the government recommendation has been suspended. However, prior trials assessing the effect of brief educational tools have shown only limited effects on increasing the willingness of parents to vaccinate their daughters. Objective: The aim of this trial is to assess the effect of a cervical cancer survivor's story on the willingness of parents to get HPV vaccination for their daughters. Methods: In this double-blinded, randomized controlled trial (RCT) implemented online, we enrolled 2175 participants aged 30-59 years in March 2020 via a webpage and provided them with a questionnaire related to the following aspects: awareness regarding HPV infection and HPV vaccination, and willingness for HPV vaccination. Participants were randomly assigned (1:1) to see a short film on a cervical cancer survivor or nothing, stratified by sex (male vs female) and willingness for HPV vaccination prior to randomization (yes vs no). The primary endpoint was the rate of parents who agreed for HPV vaccination for their daughters. The secondary endpoint was the rate of parents who agreed for HPV vaccination for their daughters and the HPV vaccination rate at 3 months. The risk ratio (RR) was used to assess the interventional effect. Results: Of 2175 participants, 1266 (58.2{\%}) were men and 909 (41.8{\%}) were women. A total of 191 (8.8{\%}) participants were willing to consider HPV vaccination prior to randomization. Only 339 (15.6{\%}) participants were aware of the benefits of HPV vaccination. In contrast, 562 (25.8{\%}) participants were aware of the adverse events of HPV vaccination. Although only 476 (21.9{\%}) of the respondents displayed a willingness to vaccinate their daughters for HPV, there were 7.5{\%} more respondents in the intervention group with this willingness immediately after watching the short film (RR 1.41, 95{\%} CI 1.20-1.66). In a subanalysis, the willingness in males to vaccinate daughters was significantly higher in the intervention group (RR 1.50, 95{\%} CI 1.25-1.81); however, such a difference was not observed among females (RR 1.21, 95{\%} CI 0.88-1.66). In the follow-up survey at 3 months, 1807 (83.1{\%}) participants responded. Of these, 149 (8.2{\%}) responded that they had had their daughters receive vaccination during the 3 months, even though we could not see the effect of the intervention: 77 (7.9{\%}) in the intervention group and 72 (8.7{\%}) in the control group. Conclusions: A cervical cancer survivor's story increases immediate willingness to consider HPV vaccination, but the effect does not last for 3 months. Furthermore, this narrative approach to parents does not increase vaccination rates in children eligible for HPV vaccination. Trial Registration: UMIN Clinical Trials Registry UMIN000039273; https://tinyurl.com/bdzjp4yf ", issn="2369-2960", doi="10.2196/34715", url="https://publichealth.www.mybigtv.com/2022/5/e34715", url="https://doi.org/10.2196/34715", url="http://www.ncbi.nlm.nih.gov/pubmed/35421848" }