@文章{信息:doi/10.2196/25803，作者="de Lusignan, Simon and Tsang, Ruby S M and Akinyemi, Oluwafunmi and Lopez Bernal, Jamie and Amirthalingam, Gayatri and Sherlock, Julian and Smith, Gillian and Zambon, Maria and Howsam, Gary and Joy, Mark"，标题="佐剂三价免疫第一季流感疫苗接种后的不良事件:回顾性队列研究"，期刊="JMIR公共卫生监测"，年="2022"，月="3"，日="28"，卷="8"，数="3"，页数="e25803"，关键词="流感;流感疫苗;相关不良事件;计算机化病历系统;背景:接种疫苗是预防季节性流感的最有效形式;英国有一个覆盖目标人群的国家流感疫苗接种计划。已知流感疫苗与一些常见的轻微不良事件(AEIs)相关，但尚不清楚在2018/2019流感季节首次提供的佐剂三价流感疫苗(aTIV)是否比其他类型的疫苗与更多的AEIs相关。目的:我们旨在比较2018/2019季节提供的不同类型季节性流感疫苗相关AEIs的发生率。方法:我们使用来自皇家全科医师学院研究和监测中心哨点网络数据库的计算机化医疗记录数据进行了一项回顾性队列研究。 We extracted data on vaccine exposure and consultations for European Medicines Agency--specified AEIs for the 2018/2019 influenza season. We used a self-controlled case series design; computed relative incidence (RI) of AEIs following vaccination; and compared the incidence of AEIs associated with aTIV, the quadrivalent influenza vaccine, and the live attenuated influenza vaccine. We also compared the incidence of AEIs for vaccinations that took place in a practice with those that took place elsewhere. Results: A total of 1,024,160 individuals received a seasonal influenza vaccine, of which 165,723 individuals reported a total of 283,355 compatible symptoms in the 2018/2019 season. Most AEIs occurred within 7 days following vaccination, with a seasonal effect observed. Using aTIV as the reference group, the quadrivalent influenza vaccine was associated with a higher incidence of AEIs (RI 1.46, 95{\%} CI 1.41-1.52), whereas the live attenuated influenza vaccine was associated with a lower incidence of AEIs (RI 0.79, 95{\%} CI 0.73-0.83). No effect of vaccination setting on the incidence of AEIs was observed. Conclusions: Routine sentinel network data offer an opportunity to make comparisons between safety profiles of different vaccines. Evidence that supports the safety of newer types of vaccines may be reassuring for patients and could help improve uptake in the future. ", issn="2369-2960", doi="10.2196/25803", url="https://publichealth.www.mybigtv.com/2022/3/e25803", url="https://doi.org/10.2196/25803", url="http://www.ncbi.nlm.nih.gov/pubmed/35343907" }